Impaired Hand Dexterity Function in a Non-human Primate Model with Chronic Parkinson's Disease

被引：1

作者：

Seo, Jincheol ^{[1
,2
]}

Won, Jinyoung ^{[1
]}

Kim, Keonwoo ^{[1
,2
]}

Park, Junghyung ^{[1
]}

Yeo, Hyeon-Gu ^{[1
,3
]}

Kim, Yu Gyeong ^{[1
,3
]}

Baek, Seung Ho ^{[1
]}

Lee, Hoonwon ^{[4
]}

Jeon, Chang-Yeop ^{[1
]}

Choi, Won Seok ^{[1
]}

Lee, Sangil ^{[5
]}

Kim, Ki Jin ^{[5
]}

Park, Sung-Hyun ^{[1
]}

Son, Yeonghoon ^{[5
]}

Jeong, Kang Jin ^{[1
]}

Lim, Kyung Seob ^{[6
]}

Kang, Philyong ^{[6
]}

Lee, Hwal-Yong ^{[6
]}

Son, Hee-Chang ^{[6
]}

Huh, Jae-Won ^{[1
,3
]}

Kim, Young-Hyun ^{[1
,3
]}

Lee, Dong-Seok ^{[2
]}

Lee, Sang-Rae ^{[1
,3
]}

Choi, Ji-Woong ^{[7
,8
]}

Lee, Youngjeon ^{[1
,3
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol KRIBB, Natl Primate Res Ctr, Cheongju 28116, South Korea

[2] Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat BioRes Grp, Daegu 41566, South Korea

[3] Korea Univ Sci & Technol, KRIBB Sch Biosci, Dept Funct Genom, Daejeon 34113, South Korea

[4] Seoul Natl Univ, Sch Biol Sci, Seoul 08826, South Korea

[5] KRIBB, Primate Resource Ctr, Jeongeup 56216, South Korea

[6] KRIBB, Futurist Anim Resource & Res Ctr, Cheongju 28116, South Korea

[7] Daegu Gyeongbuk Inst Sci & Technol DGIST, Brain Engn Convergence Res Ctr, Korea, Daegu 42988, South Korea

[8] DGIST, Dept Informat & Commun Engn, Daegu 42988, South Korea

来源：

EXPERIMENTAL NEUROBIOLOGY | 2020年 / 29卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

Parkinson's disease; Non-human primate; Hand dexterity function; Hand dexterity task; Tremor; MOTOR FUNCTION; INTRACEREBROVENTRICULAR INJECTION; FINGER DEXTERITY; POSTURAL TREMOR; ANIMAL-MODELS; MONKEY MODEL; MPTP; MOVEMENT; DIAGNOSIS; RECOVERY;

D O I：

10.5607/en20040

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Symptoms of Parkinson's disease (PD) caused by loss of dopaminergic neurons are accompanied by movement disorders, including tremors, rigidity, bradykinesia, and akinesia. Non-human primate (NHP) models with PD play an essential role in the analysis of PD pathophysiology and behavior symptoms. As impairments of hand dexterity function can affect activities of daily living in patients with PD, research on hand dexterity function in NHP models with chronic PD is essential. Traditional rating scales previously used in the evaluation of animal spontaneous behavior were insufficient due to factors related to subjectivity and passivity. Thus, experimentally designed applications for an appropriate apparatus are necessary. In this study, we aimed to longitudinally assess hand dexterity function using hand dexterity task (HDT) in NHP-PD models. To validate this assessment, we analyzed the alteration in Parkinsonian tremor signs and the functionality of presynaptic dopaminergic neuron using positron emission tomography imaging of dopamine transporters in these models. In addition, a significant inverse correlation between HDT and DAT level was identified, but no local bias was found. The correlation with intention tremor signs was lower than the resting tremor. In conclusion, the evaluation of HDT may reflect behavioral symptoms of NHP-PD models. Furthermore, HDT was effectively used to experimentally distinguish intention tremors from other tremors.

引用

页码：376 / 388

页数：13

共 52 条

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