Acetate Metabolism in Physiology, Cancer, and Beyond

被引：138

作者：

Bose, Shree ^{[1
]}

Ramesh, Vijyendra ^{[1
]}

Locasale, Jason W. ^{[1
]}

机构：

[1] Duke Univ, Sch Med, Dept Pharmacol & Canc Biol, Durham, NC 27708 USA

来源：

TRENDS IN CELL BIOLOGY | 2019年 / 29卷 / 09期

关键词：

ACETYL-COA; HISTONE ACETYLATION; GUT-MICROBIOTA; BLOOD ACETATE; LACTATE; BRAIN; CELLS; ELIMINATION; AXIS;

D O I：

10.1016/j.tcb.2019.05.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Acetate and the related metabolism of acetyl-coenzyme A (acetyl-CoA) confer numerous metabolic functions, including energy production, lipid synthesis, and protein acetylation. Despite its importance as a nutrient for cellular metabolism, its source has been unclear. Recent studies have provided evidence to support the existence of a de novo pathway for acetate production derived from pyruvate, the end product of glycolysis. This mechanism of pyruvate-derived acetate generation could have far-reaching implications for the regulation of central carbon metabolism. In this Opinion, we discuss our current understanding of acetate metabolism in the context of cell-autonomous metabolic regulation, cell-cell interactions, and systemic physiology. Applications relevant to health and disease, particularly cancer, are emphasized.

引用

页码：695 / 703

页数：9

共 60 条

[41] Acetylation of intrinsically disordered regions regulates phase separation [J].

Saito, Makoto ;

Hess, Daniel ;

Eglinger, Jan ;

Fritsch, Anatol W. ;

Kreysing, Moritz ;

Weinert, Brian T. ;

Choudhary, Chunaram ;

Matthias, Patrick .

NATURE CHEMICAL BIOLOGY, 2019, 15 (01) :51-+

[42] THE CONTRIBUTION OF THE LARGE-INTESTINE TO BLOOD ACETATE IN MAN [J].

SCHEPPACH, W ;

POMARE, EW ;

ELIA, M ;

CUMMINGS, JH .

CLINICAL SCIENCE, 1991, 80 (02) :177-182

[43] The metabolic fate of acetate in cancer [J].

Schug, Zachary T. ;

Vande Voorde, Johan ;

Gottlieb, Eyal .

NATURE REVIEWS CANCER, 2016, 16 (11) :708-717

[44] Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress [J].

Schug, Zachary T. ;

Peck, Barrie ;

Jones, Dylan T. ;

Zhang, Qifeng ;

Grosskurth, Shaun ;

Alam, Israt S. ;

Goodwin, Louise M. ;

Smethurst, Elizabeth ;

Mason, Susan ;

Blyth, Karen ;

McGarry, Lynn ;

James, Daniel ;

Shanks, Emma ;

Kalna, Gabriela ;

Saunders, Rebecca E. ;

Jiang, Ming ;

Howell, Michael ;

Lassailly, Francois ;

Thin, May Zaw ;

Spencer-Dene, Bradley ;

Stamp, Gordon ;

van den Broek, Niels J. F. ;

Mackay, Gillian ;

Bulusu, Vinay ;

Kamphorst, Jurre J. ;

Tardito, Saverio ;

Strachan, David ;

Harris, Adrian L. ;

Aboagye, Eric O. ;

Critchlow, Susan E. ;

Wakelam, Michael J. O. ;

Schulze, Almut ;

Gottlieb, Eyal .

CANCER CELL, 2015, 27 (01) :57-71

[45] Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2 [J].

Schwer, Bjoern ;

Bunkenborg, Jakob ;

Verdin, Regis O. ;

Andersen, Jens S. ;

Verdin, Eric .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (27) :10224-10229

[46] Acetyl-CoA and the regulation of metabolism: mechanisms and consequences [J].

Shi, Lei ;

Tu, Benjamin P. .

CURRENT OPINION IN CELL BIOLOGY, 2015, 33 :125-131

[47] Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation [J].

Sivanand, Sharanya ;

Viney, Isabella ;

Wellen, Kathryn E. .

TRENDS IN BIOCHEMICAL SCIENCES, 2018, 43 (01) :61-74

[48] Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice [J].

Sonveaux, Pierre ;

Vegran, Frederique ;

Schroeder, Thies ;

Wergin, Melanie C. ;

Verrax, Julien ;

Rabbani, Zahid N. ;

De Saedeleer, Christophe J. ;

Kennedy, Kelly M. ;

Diepart, Caroline ;

Jordan, Benedicte F. ;

Kelley, Michael J. ;

Gallez, Bernard ;

Wahl, Miriam L. ;

Feron, Olivier ;

Dewhirst, Mark W. .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (12) :3930-3942

[49] Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion [J].

Sousa, Cristovao M. ;

Biancur, Douglas E. ;

Wang, Xiaoxu ;

Halbrook, Christopher J. ;

Sherman, Mara H. ;

Zhang, Li ;

Kremer, Daniel ;

Hwang, Rosa F. ;

Witkiewicz, Agnes K. ;

Ying, Haoqiang ;

Asara, John M. ;

Evans, Ronald M. ;

Cantley, Lewis C. ;

Lyssiotis, Costas A. ;

Kimmelman, Alec C. .

NATURE, 2016, 536 (7617) :479-+

[50]

TOLLINGER CD, 1979, CLIN CHEM, V25, P1787

← 1 2 3 4 5 6 →