Acetate Metabolism in Physiology, Cancer, and Beyond

被引：138

作者：

Bose, Shree ^{[1
]}

Ramesh, Vijyendra ^{[1
]}

Locasale, Jason W. ^{[1
]}

机构：

[1] Duke Univ, Sch Med, Dept Pharmacol & Canc Biol, Durham, NC 27708 USA

来源：

TRENDS IN CELL BIOLOGY | 2019年 / 29卷 / 09期

关键词：

ACETYL-COA; HISTONE ACETYLATION; GUT-MICROBIOTA; BLOOD ACETATE; LACTATE; BRAIN; CELLS; ELIMINATION; AXIS;

D O I：

10.1016/j.tcb.2019.05.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Acetate and the related metabolism of acetyl-coenzyme A (acetyl-CoA) confer numerous metabolic functions, including energy production, lipid synthesis, and protein acetylation. Despite its importance as a nutrient for cellular metabolism, its source has been unclear. Recent studies have provided evidence to support the existence of a de novo pathway for acetate production derived from pyruvate, the end product of glycolysis. This mechanism of pyruvate-derived acetate generation could have far-reaching implications for the regulation of central carbon metabolism. In this Opinion, we discuss our current understanding of acetate metabolism in the context of cell-autonomous metabolic regulation, cell-cell interactions, and systemic physiology. Applications relevant to health and disease, particularly cancer, are emphasized.

引用

页码：695 / 703

页数：9

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