Acupuncture stimulation at GB34 suppresses 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced oxidative stress in the striatum of mice

被引：18

作者：

Lee, Yukyung ^{[1
]}

Choi, Gaeun ^{[1
]}

Jeon, Hyongjun ^{[1
]}

Kim, Dongsoo ^{[1
]}

Ryu, Sun ^{[2
]}

Koo, Sungtae ^{[1
,2
]}

Ha, Ki-Tae ^{[2
]}

Kim, Seungtae ^{[1
,2
]}

机构：

[1] Pusan Natl Univ, Sch Korean Med, Div Meridian & Struct Med, Busandaehak Ro 49, Yangsan Si 50612, Gyeongsangnam D, South Korea

[2] Pusan Natl Univ, Korean Med Res Ctr Hlth Aging, Yangsan Si, South Korea

来源：

JOURNAL OF PHYSIOLOGICAL SCIENCES | 2018年 / 68卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

Parkinson's disease; Acupuncture; Antioxidant; DJ-1; Superoxide dismutase; Catalase; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PARKINSONS-DISEASE; PATHWAY; MPTP; ELECTROACUPUNCTURE; MODULATION; POINTS; MODEL; CELL;

D O I：

10.1007/s12576-017-0547-7

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Recent studies have suggested that increased oxidative stress is a potential etiology in Parkinson's disease (PD). In this study, we investigated whether acupuncture regulates antioxidants in the striatum (ST) of a PD mouse model. Male C57BL/6 mice were administered 30 mg/kg of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intraperitoneally once a day for 5 days and given acupuncture stimulation at SI3 or GB34 (Yanglingquan) was for 12 consecutive days. Dopaminergic neuronal survival in the nigrostriatal pathway and DJ-1 expression in the ST was evaluated by immunostaining, and the activities of superoxide dismutase (SOD) and catalase (CAT) in the ST was by enzyme-linked immunosorbent assay. MPTP administration induced dopaminergic neuronal death in the nigrostriatal pathway, which was suppressed by acupuncture stimulation at GB34. MPTP administration also suppressed DJ-1 expression and SOD and CAT activities in the ST, which were restored by acupuncture stimulation at GB34. These results indicate that the neuroprotective effect of acupuncture stimulation is due to regulation of the antioxidants.

引用

页码：455 / 462

页数：8

共 26 条

[21] ROS removal by DJ-1 Arabidopsis as a new model to understand Parkinson disease [J].