CDK12: a potential therapeutic target in cancer

被引：25

作者：

Emadi, Fatemeh ^{[1
]}

Teo, Theodosia ^{[1
]}

Rahaman, Muhammed H. ^{[1
]}

Wang, Shudong ^{[1
]}

机构：

[1] Univ South Australia, UniSA Clin & Hlth Sci, Drug Discovery & Dev, Adelaide, SA 5000, Australia

来源：

DRUG DISCOVERY TODAY | 2020年 / 25卷 / 12期

关键词：

D O I：

10.1016/j.drudis.2020.09.035

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cyclin-dependent kinase (CDK) 12 engages in diversified biological functions, from transcription, post-transcriptional modification, cell cycle, and translation to cellular proliferation. Moreover, it regulates the expression of cancer-related genes involved in DNA damage response (DDR) and replication, which are responsible for maintaining genomic stability. CDK12 emerges as an oncogene or tumor suppressor in different cellular contexts, where its dysregulation results in tumorigenesis. Current CDK12 inhibitors are nonselective, which impedes the process of pharmacological target validation and drug development. Herein, we discuss the latest understanding of the biological roles of CDK12 in cancers and provide molecular analyses of CDK12 inhibitors to guide the rational design of selective inhibitors.

引用

页码：2257 / 2267

页数：11

共 120 条

[81] Dinaciclib (SCH727965) Inhibits the Unfolded Protein Response through a CDK1-and 5-Dependent Mechanism [J].

Nguyen, Tri K. ;

Grant, Steven .

MOLECULAR CANCER THERAPEUTICS, 2014, 13 (03) :662-674

[82] Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype [J].

Olson, Calla M. ;

Liang, Yanke ;

Leggett, Alan ;

Park, Woojun D. ;

Li, Lianbo ;

Mills, Caitlin E. ;

Elsarrag, Selma Z. ;

Ficarro, Scott B. ;

Zhang, Tinghu ;

Duester, Robert ;

Geyer, Matthias ;

Sim, Taebo ;

Marto, Jarrod A. ;

Sorger, Peter K. ;

Westover, Ken D. ;

Lin, Charles Y. ;

Kwiatkowski, Nicholas ;

Gray, Nathanael S. .

CELL CHEMICAL BIOLOGY, 2019, 26 (06) :792-+

[83] Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor [J].

Parry, David ;

Guzi, Timothy ;

Shanahan, Frances ;

Davis, Nicole ;

Prabhavalkar, Deepa ;

Wiswell, Derek ;

Seghezzi, Wolfgang ;

Paruch, Kamil ;

Dwyer, Michael P. ;

Doll, Ronald ;

Nomeir, Amin ;

Windsor, William ;

Fischmann, Thierry ;

Wang, Yaolin ;

Oft, Martin ;

Chen, Taiying ;

Kirschmeier, Paul ;

Lees, Emma M. .

MOLECULAR CANCER THERAPEUTICS, 2010, 9 (08) :2344-2353

[84] CDK12 Promotes Breast Cancer Progression and Maintains Stemness by Activating c-myc/β-catenin Signaling [J].

Peng, Fang ;

Yang, Chuansheng ;

Kong, Yanan ;

Huang, Xiaojia ;

Chen, Yanyu ;

Zhou, Yangfan ;

Xie, Xinhua ;

Liu, Peng .

CURRENT CANCER DRUG TARGETS, 2020, 20 (02) :156-165

[85] Controlling the elongation phase of transcription with P-TEFb [J].

Peterlin, B. Matija ;

Price, David H. .

MOLECULAR CELL, 2006, 23 (03) :297-305

[86]

Pishas Kathleen I, 2016, F1000Res, V5, DOI 10.12688/f1000research.8631.1

[87] Ovarian Cancers Harboring Inactivating Mutations in CDK12 Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications [J].

Popova, Tatiana ;

Manie, Elodie ;

Boeva, Valentina ;

Battistella, Aude ;

Goundiam, Oumou ;

Smith, Nicholas K. ;

Mueller, Christopher R. ;

Raynal, Virginie ;

Mariani, Odette ;

Sastre-Garau, Xavier ;

Stern, Marc-Henri .

CANCER RESEARCH, 2016, 76 (07) :1882-1891

[88] Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer [J].

Quereda, Victor ;

Bayle, Simon ;

Vena, Francesca ;

Frydman, Sylvia M. ;

Monastyrskyi, Andrii ;

Roush, William R. ;

Duckett, Derek R. .

CANCER CELL, 2019, 36 (05) :545-+

[89] Inhibition of cyclin dependent kinase 9 by dinaciclib suppresses cyclin B1 expression and tumor growth in triple negative breast cancer [J].

Rajput, Sandeep ;

Khera, Nimmish ;

Guo, Zhanfang ;

Hoog, Jeremy ;

Li, Shunqiang ;

Ma, Cynthia X. .

ONCOTARGET, 2016, 7 (35) :56864-56875

[90] CDK7 Inhibition Suppresses Castration-Resistant Prostate Cancer through MED1 Inactivation [J].

Rasool, Reyaz Ur ;

Natesan, Ramakrishnan ;

Deng, Qu ;

Aras, Shweta ;

Lal, Priti ;

Effron, Samuel Sander ;

Mitchell-Velasquez, Erick ;

Posimo, Jessica ;

Carskadon, Shannon ;

Baca, Sylvan C. ;

Pomerantz, Mark M. ;

Siddiqui, Javed ;

Schwartz, Lauren E. ;

Lee, Daniel J. ;

Palanisamy, Nallasivam ;

Narla, Goutham ;

Den, Robert B. ;

Freedman, Matthew L. ;

Brady, Donita C. ;

Asangani, Irfan A. .

CANCER DISCOVERY, 2019, 9 (11) :1538-1555

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