Overcoming Antigen Escape with CAR T-cell Therapy

被引：72

作者：

Jackson, Hollie J. ^{[1
]}

Brentjens, Renier J. ^{[1
,2
,3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Ctr Cell Engn, 1275 York Ave, New York, NY 10021 USA

[3] Mem Sloan Kettering Canc Ctr, Mol Pharmacol & Chem Program, 1275 York Ave, New York, NY 10021 USA

来源：

CANCER DISCOVERY | 2015年 / 5卷 / 12期

关键词：

D O I：

10.1158/2159-8290.CD-15-1275

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sotillo and colleagues describe the molecular events associated with apparent loss of target antigen expression following CAR T-cell therapy. We propose that broader immune activation is required to prevent outgrowth of tumor antigen escape variants following targeted therapies. (C) 2015 AACR.

引用

页码：1238 / 1240

页数：3

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