Mortality from cardiovascular diseases in the German uranium miners cohort study, 1946-1998

被引:63
作者
Kreuzer, M. [1 ]
Kreisheimer, M. [1 ]
Kandel, M. [1 ]
Schnelzer, M. [1 ]
Tschense, A. [1 ]
Grosche, B. [1 ]
机构
[1] Fed Off Radiat Protect, Dept Radiat Protect & Hlth, D-85764 Neuherberg, Germany
关键词
D O I
10.1007/s00411-006-0056-1
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
An increased risk of cardiovascular diseases after exposure to low doses of ionizing radiation has been suggested among the atomic bomb survivors. Few and inconclusive results on this issue are available from miner studies. A positive correlation between coronary heart disease mortality and radon exposure has been reported in the Newfoundland fluorspar miners study, yet low statistical power due to small sample size was of concern. To get further insight into this controversial issue, data from the German uranium miners cohort study were used, which is by far the largest miner study up to date. The cohort includes 59,001 male subjects who were employed for at least six months between 1946 and 1989 at the former Wismut uranium company in Eastern Germany. Exposure to radon, long-lived radionuclides and external gamma radiation was estimated by using a detailed job-exposure matrix. About 16,598 cohort members were deceased until 31 December 1998, including 5,417 deaths from cardiovascular diseases. Linear Poisson regression models were used to estimate the excess relative risk (ERR) per unit of cumulative radiation exposure after adjusting for attained age and calendar period. No trend in risk of circulatory diseases with increasing cumulative exposure to either radon [ERR per 100 working level month: 0.0006; 95% confidence limit (CI): - 0.004 to 0.006], external gamma radiation ( ERR per Sv: - 0.26, 95% CI: - 0.6 to 0.05) or long-lived radionuclides ( ERR per 100 kBqh/m(3): - 0.2, 95% CI: - 0.5 to 0.06), respectively, was observed. This was also true for the sub-group heart disease and stroke. Our findings do not support an association between cardiovascular disease mortality and exposure to radiation among miners, yet low doses and uncontrolled confounding hamper interpretation.
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页码:159 / 166
页数:8
相关论文
共 32 条
  • [1] [Anonymous], 1998, BELASTUNG DURCH IONI
  • [2] Brüske-Hohlfeld I, 2006, HEALTH PHYS, V90, P208
  • [3] Coronary heart disease after radiotherapy for peptic ulcer disease
    Carr, ZA
    Land, CE
    Kleinerman, RA
    Weinstock, RW
    Stovall, M
    Griem, ML
    Mabuchi, K
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2005, 61 (03): : 842 - 850
  • [4] Mortality from cardiovascular disease more than 10 years after radiotherapy for breast cancer: nationwide cohort study of 90 000 Swedish women
    Darby, S
    McGale, P
    Peto, R
    Granath, F
    Hall, P
    Ekbom, A
    [J]. BRITISH MEDICAL JOURNAL, 2003, 326 (7383): : 256 - 257
  • [5] Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials
    Early Breast Cancer Trialists' Collaborative Group
    [J]. LANCET, 2000, 355 (9217) : 1757 - 1770
  • [6] FACTORS AFFECTING LATE MORTALITY FROM HEART-DISEASE AFTER TREATMENT OF HODGKINS-DISEASE
    HANCOCK, SL
    TUCKER, MA
    HOPPE, RT
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 270 (16): : 1949 - 1955
  • [7] HARLEY NH, 1992, RADIAT PROT DOSIM, V45, P619
  • [8] Mortality from diseases of the circulatory system in radiologic technologists in the United States
    Hauptmann, M
    Mohan, AK
    Doody, MM
    Linet, MS
    Mabuchi, K
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 2003, 157 (03) : 239 - 248
  • [9] JACOBI W, 1995, RISIKO VERURSACHUNGS
  • [10] Doses to organs and tissues from radon and its decay products
    Kendall, Gerry M.
    Smith, T.J.
    [J]. Journal of Radiological Protection, 2002, 22 (04) : 389 - 406