Modeling the second wave of COVID-19 infections in France and Italy via a stochastic SEIR model

被引:59
作者
Faranda, Davide [1 ,2 ,3 ,4 ]
Alberti, Tommaso [5 ]
机构
[1] Univ Paris Saclay, CNRS, Lab Sci Climat & Environm, CEA Saclay Orme Merisiers,CEA,UVSQ,UMR 8212, F-91191 Gif Sur Yvette, France
[2] IPSL, F-91191 Gif Sur Yvette, France
[3] London Math Lab, 8 Margravine Gardens, London W6 8RH, England
[4] PSL Res Univ, Ecole Normale Super, LMD, IPSL, F-75005 Paris, France
[5] INAF Ist Astrofis & Planetol Spaziali, Via Fosso Cavaliere 100, I-00133 Rome, Italy
关键词
EPIDEMIC; DYNAMICS; SPREAD; EVENTS;
D O I
10.1063/5.0015943
中图分类号
O29 [应用数学];
学科分类号
070104 ;
摘要
COVID-19 has forced quarantine measures in several countries across the world. These measures have proven to be effective in significantly reducing the prevalence of the virus. To date, no effective treatment or vaccine is available. In the effort of preserving both public health and the economical and social textures, France and Italy governments have partially released lockdown measures. Here, we extrapolate the long-term behavior of the epidemic in both countries using a susceptible-exposed-infected-recovered model, where parameters are stochastically perturbed with a lognormal distribution to handle the uncertainty in the estimates of COVID-19 prevalence and to simulate the presence of super-spreaders. Our results suggest that uncertainties in both parameters and initial conditions rapidly propagate in the model and can result in different outcomes of the epidemic leading or not to a second wave of infections. Furthermore, the presence of super-spreaders adds instability to the dynamics, making the control of the epidemic more difficult. Using actual knowledge, asymptotic estimates of COVID-19 prevalence can fluctuate of the order of 10 x 10 6 units in both countries.
引用
收藏
页数:13
相关论文
共 72 条
[1]   Super-spreading events and contribution to transmission of MERS, SARS, and SARS-CoV-2 (COVID-19) [J].
Al-Tawfiq, J. A. ;
Rodriguez-Morales, A. J. .
JOURNAL OF HOSPITAL INFECTION, 2020, 105 (02) :111-112
[2]   On the uncertainty of real-time predictions of epidemic growths: A COVID-19 case study for China and Italy [J].
Alberti, Tommaso ;
Faranda, Davide .
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION, 2020, 90
[3]   How will country-based mitigation measures influence the course of the COVID-19 epidemic? [J].
Anderson, Roy M. ;
Heesterbeek, Hans ;
Klinkenberg, Don ;
Hollingsworth, T. Deirdre .
LANCET, 2020, 395 (10228) :931-934
[4]  
Andersson H., 2012, Stochastic Epidemic Models and Their Statistical Analysis, V151
[5]  
[Anonymous], 2020, ABC NEWS
[6]  
[Anonymous], 2020, COR MIL 41ENN FEBBR
[7]  
[Anonymous], 2020, COM VANN LETT DAT CO
[8]  
[Anonymous], 2020, Coronavirus disease 2019 (COVID-19): situation report, P51
[9]  
Arin K, 2020, THE KOREA HERALD
[10]  
Brauer F, 2008, LECT NOTES MATH, V1945, P19