The prognostic impact of the neutrophil-to-lymphocyte ratio in patients with small-cell lung cancer

被引：176

作者：

Kang, M. H. ^{[1
]}

Go, S-I ^{[1
]}

Song, H-N ^{[1
]}

Lee, A. ^{[1
]}

Kim, S-H ^{[2
]}

Kang, J-H ^{[1
,3
]}

Jeong, B-K ^{[4
]}

Kang, K. M. ^{[4
]}

Ling, H. ^{[5
]}

Lee, G-W ^{[1
,3
]}

机构：

[1] Gyeongsang Natl Univ, Sch Med, Gyeongsang Natl Univ Hosp, Dept Internal Med,Div Hematol Oncol, Jinju, South Korea

[2] Sungkyunkwan Univ, Sch Med, Samsung Changwon Hosp, Dept Internal Med,Div Hematol & Med Oncol, Chang Won, South Korea

[3] Gyeongsang Inst Hlth Sci, Jinju, South Korea

[4] Gyeongsang Natl Univ, Sch Med, Gyeongsang Natl Univ Hosp, Dept Radiat Oncol, Jinju, South Korea

[5] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA

来源：

BRITISH JOURNAL OF CANCER | 2014年 / 111卷 / 03期

关键词：

neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; overall survival; C-REACTIVE PROTEIN; EXTRACELLULAR TRAPS; TUMOR-CELLS; CARCINOMA; INFLAMMATION; STAGE; PHENOTYPE; RESPONSES; ELASTASE; MARKERS;

D O I：

10.1038/bjc.2014.317

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are prognostic factors for various types of cancer. In this study, we assessed the association of NLR and PLR with the prognosis of small-cell lung cancer (SCLC) in patients who received the standard treatment. Methods: We retrospectively reviewed patients who were diagnosed with SCLC and treated with platinum-based chemotherapy between July 2006 and October 2013 in Gyeongsang National University Hospital Regional Cancer Center and Changwon Samsung Hospital. Results: In total, 187 patients were evaluated. Compared with low NLR (<4), high NLR (>= 4) at diagnosis was associated with poor performance status, advanced stage, and lower response rate. Median overall survival (OS) and progression-free survival (PFS) were worse in the high-NLR group (high vs low, 11.17 vs 9.20 months, P = 0.019 and 6.90 vs 5.49 months, P = 0.005, respectively). In contrast, PLR at diagnosis was not associated with OS or PFS (P = 0.467 and P = 0.205, respectively). In multivariate analysis, stage, lactate dehydrogenase, and NLR at diagnosis were independent prognostic factors for OS and PFS. Conclusions: NLR is easily measurable and reflects the SCLC prognosis. A future prospective study is warranted to confirm our results.

引用

页码：452 / 460

页数：9

共 48 条

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