Better Neutralization of Herpes Simplex Virus Type 1 (HSV-1) Than HSV-2 by Antibody From Recipients of GlaxoSmithKline HSV-2 Glycoprotein D2 Subunit Vaccine

被引：53

作者：

Awasthi, Sita ^{[1
]}

Belshe, Robert B. ^{[2
]}

Friedman, Harvey M. ^{[1
]}

机构：

[1] Univ Penn, Div Infect Dis, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] St Louis Univ, Div Infect Dis Allergy & Immunol, St Louis, MO 63103 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2014年 / 210卷 / 04期

关键词：

HSV-1; HSV-2; vaccine; glycoprotein D; glycoprotein C; glycoprotein E; neutralizing antibody; Herpevac Trial; IMMUNE EVASION; ENTRY;

D O I：

10.1093/infdis/jiu177

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Herpevac Trial evaluated a herpes simplex virus type 2 (HSV-2) glycoprotein D (gD2) subunit vaccine to prevent genital herpes. Unexpectedly, the vaccine protected against genital HSV-1 infection but not genital HSV-2 infection. We evaluated sera from 30 women seronegative for HSV-1 and HSV-2 who were immunized with gD2 in the Herpevac Trial. Neutralizing antibody titers to HSV-1 were 3.5-fold higher than those to HSV-2 (P<.001). HSV-2 gC2 and gE2 on the virus blocked neutralization by gD2 antibody, while HSV-1 gC1 and gE1 did not block neutralization by gD2 antibody. The higher neutralizing antibody titers to HSV-1 offer an explanation for the Herpevac results, and shielding neutralizing domains provides a potential mechanism.

引用

页码：571 / 575

页数：5

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