CD4/CD8 dual-positive mycosis fungoides A case report and literature review

被引：2

作者：

Ding, Xiaojie ^{[1
]}

Chen, Jia ^{[2
]}

Kuai, Le ^{[1
]}

Xing, Meng ^{[1
]}

Ru, Yi ^{[1
,3
]}

Luo, Ying ^{[1
,3
]}

Luo, Yue ^{[1
]}

Zhou, Mi ^{[1
]}

Li, Bin ^{[1
,3
]}

Li, Xin ^{[1
,3
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Dept Dermatol, Yueyang Hosp Integrated Tradit Chinese & Western, Shanghai, Peoples R China

[2] Tongji Univ, Shanghai Dermatol Hosp, Dept Dermatopathol, Shanghai, Peoples R China

[3] Shanghai Acad Tradit Chinese Med, Inst Dermatol, Shanghai, Peoples R China

来源：

MEDICINE | 2020年 / 99卷 / 42期

关键词：

case report; CD4; CD8; double positive; herbal medicine; mycosis fungoides; PHENOTYPE;

D O I：

10.1097/MD.0000000000022786

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rationale: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma. It appears as patches, plaques, and tumors depending on the stage of the disease, which presents a chronic progressive course. Compared to CD4(+)/CD8(-) MF, CD4/CD8 dual-positive MF is an uncommon immune phenotype. Patient Concerns: A 36-year-old male patient presented with dryness and scales on his whole body. Diagnosis: The patient was diagnosed with MF based on results of pathological examination, immunohistochemical staining, and T-cell receptor gene rearrangement test. Interventions: The patient was advised to take an herbal medicine orally twice daily and apply a topical moisturizer after showering. Outcomes: After treatment and follow-up, the patient's symptoms of dryness and scales improved and his condition stabilized. Conclusions: While reviewing the literature, we found no previous reports on the treatment of dual-positive MF with Chinese medicine. In this report, we presented the first case of dual-positive MF successfully treated with Chinese medicine. The results suggest that oral ingestion of herbal medicine may be a feasible method for alleviating clinical symptoms of early stage MF. Therefore, the therapy should be explored for clinical use in the future.

引用

页数：10

共 29 条

[1] MYCOSIS-FUNGOIDES AND SEZARY-SYNDROME IN JAPAN - CLINICOPATHOLOGICAL STUDY OF 107 AUTOPSY CASES [J].