Effects of Leukoreduction and Premedication With Acetaminophen and Diphenhydramine in Minimizing Febrile Nonhemolytic Transfusion Reactions and Allergic Transfusion Reactions During and After Blood Product Administration: A Literature Review With Recommendations for Practice

被引:11
作者
Duran, Joana [1 ]
Siddique, Sulman [2 ]
Cleary, Myra [3 ]
机构
[1] Duke Univ, Durham, NC 27710 USA
[2] Cure2Children Fdn, Dept Int Nursing, London, England
[3] Childrens Natl Med Ctr, Chron Blood Transfus Program, Washington, DC 20010 USA
关键词
hematology; transfusions; adverse events; leukoreduction; premedication; CONTROLLED-TRIAL; PLACEBO; PREVENTION; GUIDELINES; REDUCTION; RBCS;
D O I
10.1177/1043454214532029
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Transfusion-related reactions cause unwanted interruptions in blood-product administration and potential complications for patients. The most common reactions are febrile nonhemolytic transfusion reactions (FNHTRs) and allergic transfusion reactions (ATRs). The presence of leukocytes in blood products has been associated with these reactions, and efficacy of leukoreduction in minimizing FNHTRs and ATRs has recently been investigated. In addition, premedication with acetaminophen and diphenhydramine is the most widely used practice in minimizing FNHTRs and ATRs, yet the benefit of this is not supported by research. The aim of this systematic literature review was to evaluate the potential benefits of both of these interventions in minimizing FNHTRs and ATRs and provide recommendations for practice. We found moderate quality evidence with strong recommendations for the practice of leukoreduction in minimizing FNHTRs but not ATRs. We did not find evidence to support the use of premedications in minimizing transfusion-related reactions, and we question the need for this practice in settings where leukoreduction is used.
引用
收藏
页码:223 / 229
页数:7
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