Impact of statin use on biochemical recurrence in patients treated with radical prostatectomy

被引：15

作者：

Rieken, M. ^{[1
,2
]}

Kluth, L. A. ^{[1
,3
]}

Xylinas, E. ^{[1
,4
]}

Seitz, C. ^{[5
]}

Fajkovic, H. ^{[5
]}

Karakiewicz, P. I. ^{[6
]}

Lotan, Y. ^{[7
]}

Briganti, A. ^{[8
]}

Loidl, W. ^{[9
]}

Faison, T. ^{[1
]}

Crivelli, J. J. ^{[1
]}

Scherr, D. S. ^{[1
]}

Bachmann, A. ^{[2
]}

Tewari, A. K. ^{[1
]}

Kautzky-Willer, A. ^{[10
]}

Pummer, K. ^{[11
]}

Shariat, S. F. ^{[1
,5
]}

机构：

[1] New York Presbyterian Hosp, Weill Cornell Med Coll, Dept Urol, New York, NY USA

[2] Univ Basel Hosp, Dept Urol, CH-4031 Basel, Switzerland

[3] Univ Med Ctr Hamburg Eppendorf, Dept Urol, Hamburg, Germany

[4] Univ Paris 05, Cochin Hosp, AP HP, Dept Urol, Paris, France

[5] Med Univ Vienna, Dept Urol, A-1090 Vienna, Austria

[6] Univ Montreal, Dept Urol, Montreal, PQ, Canada

[7] Univ Texas SW Med Ctr Dallas, Dept Urol, Dallas, TX 75390 USA

[8] Ist Sci San Raffaele, Urol Res Inst, Dept Urol, I-20132 Milan, Italy

[9] Hosp Barmherzige Schwestern Linz, Prostate Canc Ctr, Linz, Austria

[10] Med Univ Vienna, Dept Internal Med 3, Div Endocrinol & Metab, Unit Gender Med, A-1090 Vienna, Austria

[11] Med Univ Graz, Dept Urol, Graz, Austria

来源：

PROSTATE CANCER AND PROSTATIC DISEASES | 2013年 / 16卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

statins; radical prostatectomy; biochemical recurrence; HOSPITAL SEARCH DATABASE; CANCER RECURRENCE; RADIATION-THERAPY; METAANALYSIS; OUTCOMES; RADIOTHERAPY; CHOLESTEROL; RISK; MEN;

D O I：

10.1038/pcan.2013.31

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BACKGROUND: The impact of statin use on biochemical recurrence (BCR) in patients treated with radical prostatectomy (RP) remains controversial. METHODS: We retrospectively evaluated 6842 patients who underwent RP for clinically localized prostate cancer (PC) between 2000 and 2011. Uni- and multivariable cox regression models addressed the association of statin use with BCR. RESULTS: Overall, 2275 (33.3%) patients used statins. Statin users were older and had a higher rate of positive surgical margins than patients not using statins (P-values <= 0.05). Within a median follow-up of 25 months (interquartile range: 8-42 months), 778 (11.4%) patients experienced BCR. Actuarial estimate 5-years BCR-free survival was 82% +/- 1 for patients without statin use and 84 +/- 1% for patients using statins (P = 0.05); statin use was not associated with BCR (hazard ratio: 0.88, 95% confidence interval: 0.76-1.03, P = 0.10) after adjusting for the effects of standard clinicopathologic features. CONCLUSIONS: In PC patients undergoing RP, statin use was not independently associated with lower risk of BCR.

引用

页码：367 / 371

页数：5

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