Therapeutic Drug Management for Transplanted Women with a Planned Pregnancy: About Two Cases of Lung and Heart-lung Transplantation

被引：0

作者：

Zecchini, Celine ^{[1
]}

Chanoine, Sebastien ^{[1
,2
]}

Chapuis, Claire ^{[1
]}

Claustre, Johanna ^{[3
]}

Schir, Edith ^{[4
]}

Allenet, Benoit ^{[1
,2
]}

Saint Raymond, Christel ^{[3
]}

Bedouch, Pierrick ^{[1
,2
]}

机构：

[1] CHU Grenoble, Pole Pharm, F-38043 Grenoble 9, France

[2] Univ Grenoble Alpes, CNRS, ThEMAS TIMC UMR 5525, Grenoble, France

[3] CHU Grenoble, Clin Univ Pneumol, F-38043 Grenoble 9, France

[4] Ctr Reg Pharmacovigilance, Grenoble, France

来源：

THERAPIE | 2015年 / 70卷 / 06期

关键词：

pregnancy; lung transplantation; drugs; immunosuppressants; teratogenicity; STATIN USE; EXPOSURE; AZATHIOPRINE; SURVIVAL; OUTCOMES;

D O I：

10.2515/therapie/2015033

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Advances in lung transplantation allow the women of childbearing age to consider becoming mothers. When planning to become pregnant, a therapeutic drug management of immunosuppressive drugs and associated therapies is required. It must take into account teratogenic and fetotoxic drugs, as well as pharmacokinetic changes encountered during pregnancy. Increasingly data are currently available on the management of immunosuppressive drugs and associated therapies during pregnancy. We report the case management of drug therapy before and during pregnancy in two patients after a lung or heart-lung transplantation. To prevent the emergence of complications for mother and child, a literature review has been necessary to manage drug therapies of each patient.

引用

页码：493 / 499

页数：7

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