Molecular Epidemiology and Mechanisms of Carbapenem Resistance of Acinetobacter spp. in Asia and Oceania

被引：42
作者：
Kamolvit, Witchuda [1 ,2 ]
Sidjabat, Hanna E. [1 ]
Paterson, David L. [1 ]
机构：
[1] Univ Queensland, UQ Ctr Clin Res, Brisbane, Qld 4029, Australia
[2] Mahidol Univ, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand
来源：
MICROBIAL DRUG RESISTANCE | 2015年 / 21卷 / 04期
关键词：
METALLO-BETA-LACTAMASE; FIELD GEL-ELECTROPHORESIS; GRAM-NEGATIVE BACTERIA; CALCOACETICUS-BAUMANNII COMPLEX; OUTER-MEMBRANE PROTEIN; INTENSIVE-CARE-UNIT; GLOBAL CLONE 2; MULTIDRUG-RESISTANCE; GENETIC STRUCTURES; HIGH PREVALENCE;
D O I：
10.1089/mdr.2014.0234
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Acinetobacter baumannii is emerging as a pathogen that is commonly involved in nosocomial infections. A. baumannii has exhibited the ability to develop multidrug resistance (MDR), including resistance to carbapenems, the last-line class of antibiotics to treat these infections. In particular, MDR A. baumannii International Clone (IC) 2 has disseminated worldwide causing substantial problems in hospitals, including in Asia and Oceania. The global spread of this clonal lineage emphasizes the importance of tracking molecular epidemiology to obtain greater understanding of the population dynamics of A. baumannii. Carbapenem resistance in A. baumannii occurs mainly as a result of acquisition of OXA-type carbapenemase genes, and to some extent by acquisition of metallo--lactamase genes. The acquisition of carbapenemase genes, particularly the bla(OXA-23), bla(OXA-40), and bla(OXA-58), by specific clonal lineages may be one of the attributes responsible for the relative homogeneity of the MDR A. baumannii population.
引用
收藏
页码：424 / 434
页数：11
相关论文
共 117 条
[1]   Genomewide Analysis of Divergence of Antibiotic Resistance Determinants in Closely Related Isolates of Acinetobacter baumannii [J].
Adams, Mark D. ;
Chan, E. Ricky ;
Molyneaux, Neil D. ;
Bonomo, Robert A. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (09) :3569-3577
[2]   Characterization of OXA-25, OXA-26, and OXA-27, molecular class D β-lactamases associated with carbapenem resistance in clinical isolates of Acinetobacter baumannii [J].
Afzal-Shah, M ;
Woodford, N ;
Livermore, DM .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (02) :583-588
[3]   blaIMP and blaVIM mediated carbapenem resistance in Pseudomonas and Acinetobacter species in India [J].
Amudhan, M. Shanthi ;
Sekar, Uma ;
Kamalanathan, Arunagiri ;
Balaraman, Sekar .
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, 2012, 6 (11) :757-762
[4]  
[Anonymous], J ANTIMICROB CHEMOTH
[5]   Mortality associated with Pandrug-resistant Acinetobacter baumannii infections in Thailand [J].
Apisarnthanarak, Anucha ;
Mundy, Linda M. .
AMERICAN JOURNAL OF INFECTION CONTROL, 2009, 37 (06) :519-520
[6]   Development of a multilocus sequence typing scheme for characterization of clinical isolates of Acinetobacter baumannii [J].
Bartual, SG ;
Seifert, H ;
Hippler, C ;
Luzon, MAD ;
Wisplinghoff, H ;
Rodríguez-Valera, F .
JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (09) :4382-4390
[7]   Evaluation of the ability of a commercial system to identify Acinetobacter genomic species [J].
Bernards, AT ;
vanderToorn, J ;
vanBoven, CPA ;
Dijkshoorn, L .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1996, 15 (04) :303-308
[8]   16S rRNA gene sequencing versus the API 20 NE system and the VITEK 2 ID-GNB card for identification of nonfermenting gram-negative bacteria in the clinical laboratory [J].
Bosshard, PP ;
Zbinden, R ;
Abels, S ;
Böddinghaus, B ;
Altwegg, M ;
Böttger, EC .
JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (04) :1359-1366
[9]   The sequences of seven class D β-lactamases isolated from carbapenem-resistant Acinetobacter baumannii from four continents [J].
Brown, S ;
Amyes, SGB .
CLINICAL MICROBIOLOGY AND INFECTION, 2005, 11 (04) :326-329
[10]   Characterisation of OXA-51, a novel class D carbapenemase found in genetically unrelated clinical strains of Acinetobacter baumannii from Argentina [J].
Brown, S ;
Young, HK ;
Amyes, SGB .
CLINICAL MICROBIOLOGY AND INFECTION, 2005, 11 (01) :15-23
12345678910