Gastric xanthelasma may be a warning sign for the presence of early gastric cancer

被引：50
作者：
Sekikawa, Akira [1 ]
Fukui, Hirokazu [2 ]
Maruo, Takanori [1 ]
Tsumura, Takehiko [1 ]
Kanesaka, Takashi [1 ]
Okabe, Yoshihiro [1 ]
Osaki, Yukio [1 ]
机构：
[1] Osaka Red Cross Hosp, Dept Gastroenterol & Hepatol, Osaka 5438555, Japan
[2] Hyogo Coll Med, Div Upper Gastroenterol, Dept Internal Med, Nishinomiya, Hyogo 6638501, Japan
来源：
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2014年 / 29卷 / 05期
关键词：
age; atrophic gastritis; gastric cancer; gastric xanthelasma; HELICOBACTER-PYLORI INFECTION; RISK; ASSOCIATION; PEPSINOGEN; CARCINOMA; COHORT; ANTIBODY; LESIONS;
D O I：
10.1111/jgh.12512
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Background and AimThe significance of gastric xanthelasma in relation to gastric disease still remains unclear. We investigated the prevalence and significance of gastric xanthelasma in patients with atrophic gastritis and gastric cancer. MethodsA total of 3238 patients who underwent endoscopic examinations of the upper gastrointestinal tract were enrolled. We retrospectively investigated the presence of gastric xanthelasma, the severity of gastric atrophy, and the presence of gastric cancer, and examined the relationship between gastric xanthelasma and various clinicopathological features. ResultsGastric xanthelasma was detected in 249 (7.7%) of the 3238 patients and was significantly associated with age 65 years, male gender, open-type atrophy, and the presence of gastric cancer (P<0.0001, P=0.0002, P<0.0001 and P<0.0001, respectively). Multivariate analysis revealed that the presence of gastric cancer was independently related to the presence of gastric xanthelasma (odds ratio 6.19 [3.95-9.70], P<0.0001). Age/sex/atrophy-matched control analysis demonstrated that the presence of gastric xanthelasma was significantly associated with the presence of gastric cancer (P<0.0001). Moreover, the presence of xanthelasma in the upper region of the stomach was significantly associated with gastric cancer (P=0.002). Gastric xanthelasma was observed in 50 (47.6%) of 105 patients with gastric cancer. ConclusionGastric xanthelasma may serve as a warning sign for the presence of gastric cancer.
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页码：951 / 956
页数：6
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