The diagnosis and treatment of hepatocellular carcinoma

被引：541

作者：

Hartke, Justin ^{[1
]}

Johnson, Matthew ^{[2
]}

Ghabril, Marwan ^{[1
]}

机构：

[1] Gastroenterol & Hepatol, Madison, WI USA

[2] Indiana Univ, Sch Med, Intervent Radiol, Indianapolis, IN 46202 USA

来源：

SEMINARS IN DIAGNOSTIC PATHOLOGY | 2017年 / 34卷 / 02期

关键词：

Cirrhosis; Diagnosis; Treatment; Locoregional therapy; Resection; Liver transplantation; Barcelona Clinic Liver Cancer system; Screening; SERUM ALPHA-FETOPROTEIN; CHRONIC HEPATITIS-C; 7 STAGING SYSTEMS; LIVER-TRANSPLANTATION; PROGNOSTIC-FACTORS; UNITED-STATES; RISK-FACTORS; EXTRAHEPATIC METASTASES; DYSPLASTIC NODULES; NODE-METASTASIS;

D O I：

10.1053/j.semdp.2016.12.011

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Hepatocellular carcinoma is a leading cancer worldwide. Its incidence is increasing, and is closely related to advanced liver disease. Cirrhosis represents the greatest risk factor for this malignancy, and is the main indication for screening and surveillance. The diagnosis of hepatocellular carcinoma can frequently, and uniquely, be made on characteristic multiphase contrast based cross-sectional imaging rather than strict need for tissue sampling. Despite advances in medical, locoregional and surgical therapies, hepatocellular carcinoma remains one of the most common causes of cancer-related death globally. In this review, current approaches to management of hepatocellular carcinoma are discussed, which incorporate both tumor and patient factors. The salient considerations in surgical (resection, liver transplantation), locoregional (ablation and embolic therapies) and medical therapies are highlighted. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：153 / 159

页数：7

共 116 条

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