Effect of extraction temperature and solvent type on the bioactive potential of Ocimum gratissimum L. extracts

被引：62
作者：
Onyebuchi, Confidence [1 ]
Kavaz, Doga [1 ,2 ]
机构：
[1] Cyprus Int Univ, Fac Engn, Bioengn Dept, Northern Cyprus Via Mersin 10, TR-98258 Nicosia, Turkey
[2] Cyprus Int Univ, Biotechnol Res Ctr, Northern Cyprus Via Mersin 10, TR-99258 Nicosia, Turkey
来源：
SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期
关键词：
ANTIOXIDANT ACTIVITY; ESSENTIAL OIL; KINETICS; ANTHOCYANINS; DEGRADATION; CAPACITY; IMPACT; ACID;
D O I：
10.1038/s41598-020-78847-5
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Ocimum gratissimum is a shrub that belongs to the Lamiaceae family of plants. Despite the known biological activities and ethnomedicinal applications, comparative evaluation of the effects of different extraction techniques on the chemical and bioactive properties of O. gratissimum extracts has not yet been performed. This study adopted different analytical techniques to determine the effect of extraction temperature and solvent type on the phytochemical and bioactive properties of O. gratissimum extracts. Chemical profiling showed increased concentrations of compounds for both the ethanolic and methanolic extracts compared to the water extracts. The results also revealed that the extraction temperature had an effect on the total phenolic content and radical-scavenging properties of the different extracts. The antioxidant kinetic modeling achieved the best fit when using the second-order kinetic model. Methanolic extracts had the highest levels of antibacterial activity against Escherichia coli, Bacillus cereus, Staphylococcus aureus, and Salmonella typhimurium. At high concentrations, all extracts lowered the viability of the breast cancer cell line MDA-MB-231. In conclusion, the chemical and bioactive properties of all extracts showed significant dependence on the extraction temperature and solvent type. With proper extraction methods, they boast a wide range of promising applications in the medical, pharmaceutical, and food industries.
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页数：11
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