Antibody Responses to SARS-CoV-2 Antigens in Humans and Animals

被引：12

作者：

Kim, Hyunsuh ^{[1
]}

Seiler, Patrick ^{[1
]}

Jones, Jeremy C. ^{[1
]}

Ridout, Granger ^{[2
]}

Camp, Kristi P. ^{[3
]}

Fabrizio, Thomas P. ^{[1
]}

Jeevan, Trushar ^{[1
]}

Miller, Lance A. ^{[1
]}

Throm, Robert E. ^{[4
]}

Ferrara, Francesca ^{[4
]}

Fredrickson, Richard L. ^{[5
]}

Lowe, James F. ^{[6
]}

Wang, Leyi ^{[7
,8
]}

Odemuyiwa, Solomon O. ^{[9
]}

Wan, Xiu-Feng ^{[9
]}

Webby, Richard J. ^{[1
,10
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Hartwell Ctr Bioinformat & Biotechnol, Memphis, TN 38105 USA

[3] Eastgate Anim Clin, Memphis, TN 38117 USA

[4] St Jude Childrens Res Hosp, Vector Dev & Prod, Memphis, TN 38105 USA

[5] Univ Illinois, Vet Diagnost Lab, Coll Vet Med, Urbana, IL 61820 USA

[6] Univ Illinois, Integrated Food Anim Management Syst, Dept Vet Clin Med, Coll Vet Med, Urbana, IL 61820 USA

[7] Univ Illinois, Dept Vet Clin Med, Coll Vet Med, Urbana, IL 61820 USA

[8] Univ Illinois, Vet Diagnost Lab, Coll Vet Med, Urbana, IL 61820 USA

[9] Univ Missouri, Dept Vet Pathobiol, Coll Vet Med, Columbia, MO 65211 USA

[10] Univ Tennessee, Dept Microbiol Immunol & Biochem, Coll Med, Hlth Sci Ctr, Memphis, TN 38163 USA

来源：

VACCINES | 2020年 / 8卷 / 04期

关键词：

SARS-CoV-2; COVID-19; respiratory viruses; antibody; vaccine; RESPIRATORY SYNDROME CORONAVIRUS; INFECTION;

D O I：

10.3390/vaccines8040684

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To optimize the public health response to coronavirus disease 2019 (COVID-19), we must first understand the antibody response to individual proteins on the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and the antibody's cross reactivity to other coronaviruses. Using a panel of 37 convalescent COVID-19 human serum samples, we showed that the magnitude and specificity of responses varied across individuals, independent of their reactivity to seasonal human coronaviruses (HCoVs). These data suggest that COVID-19 vaccines will elicit primary humoral immune responses in naive individuals and variable responses in those previously exposed to SARS-CoV-2. Unlike the limited cross-coronavirus reactivities in humans, serum samples from 96 dogs and 10 cats showed SARS-CoV-2 protein-specific responses focused on non-S1 proteins. The correlation of this response with those to other coronaviruses suggests that the antibodies are cross-reactive and generated to endemic viruses within these hosts, which must be considered in seroepidemiologic studies. We conclude that substantial variation in antibody generation against coronavirus proteins will influence interpretations of serologic data in the clinical and veterinary settings.

引用

页码：1 / 15

页数：15

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