Simpson's Paradox in Survival Models

被引:8
作者
Di Serio, Clelia [2 ]
Rinott, Yosef [1 ,3 ,4 ]
Scarsini, Marco [1 ]
机构
[1] LUISS, Dipartimento Sci Econ & Aziendali, I-00197 Rome, Italy
[2] Univ Vita Salute San Raffaele, Dipartimento Psicol, Milan, Italy
[3] Hebrew Univ Jerusalem, Dept Stat, IL-91905 Jerusalem, Israel
[4] Hebrew Univ Jerusalem, Ctr Study Rat, IL-91905 Jerusalem, Israel
基金
以色列科学基金会;
关键词
Cox model; detrimental covariate; linear transformation model; omitting covariates; positive dependence; proportional hazard; proportional odds model; protective covariate; total positivity; PROPORTIONAL HAZARDS MODEL; REGRESSION-MODELS; SCORE TESTS; MISSPECIFICATION; TRANSFORMATIONS; INFERENCE;
D O I
10.1111/j.1467-9469.2008.00637.x
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
In the context of survival analysis it is possible that increasing the value of a covariate X has a beneficial effect on a failure time, but this effect is reversed when conditioning on any possible value of another covariate Y. When studying causal effects and influence of covariates on a failure time, this state of affairs appears paradoxical and raises questions about the real effect of X. Situations of this kind may be seen as a version of Simpson's paradox. In this paper, we study this phenomenon in terms of the linear transformation model. The introduction of a time variable makes the paradox more interesting and intricate: it may hold conditionally on a certain survival time, i.e. on an event of the type {T > t} for some but not all t, and it may hold only for some range of survival times.
引用
收藏
页码:463 / 480
页数:18
相关论文
共 39 条
[1]   Simpson's paradox and the Bayes factor [J].
Aitkin, M .
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1998, 60 :269-270
[2]  
ANDERSON GL, 1995, BIOMETRIKA, V82, P527, DOI 10.1093/biomet/82.3.527
[3]  
[Anonymous], 1972, J Roy Stat Soc B
[4]  
[Anonymous], 1968, TOTAL POSITIVITY
[5]  
Bennett S, 1983, Stat Med, V2, P273, DOI 10.1002/sim.4780020223
[6]  
BENNETT S, 1983, APPL STAT-J ROY ST C, V32, P165
[7]   SIMPSONS PARADOX AND MUTUALLY FAVORABLE EVENTS [J].
BLYTH, CR .
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1973, 68 (343) :746-746
[8]   AN ANALYSIS OF TRANSFORMATIONS [J].
BOX, GEP ;
COX, DR .
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1964, 26 (02) :211-252
[9]   COVARIANCE ANALYSIS OF CENSORED SURVIVAL DATA [J].
BRESLOW, N .
BIOMETRICS, 1974, 30 (01) :89-99
[10]  
BRETAGNOLLE J, 1988, SCAND J STAT, V15, P125