Synthesis, Characterization, and Antimicrobial Activity of New Thienopyrimidine Derivatives

被引：21

作者：

Ahmed, Mostafa ^{[1
]}

Sayed, Mostafa ^{[1
]}

Saber, Ahmed F. ^{[2
]}

Hassanien, Reda ^{[1
]}

Kamal El-Dean, Adel M. ^{[2
]}

Tolba, Mahmoud S. ^{[1
]}

机构：

[1] New Valley Univ, Fac Sci, Dept Chem, New Valley 72511, Egypt

[2] Assiut Univ, Fac Sci, Dept Chem, Assiut, Egypt

来源：

POLYCYCLIC AROMATIC COMPOUNDS | 2022年 / 42卷 / 06期

关键词：

Synthesis; thienopyrimidne; triazine; triazole;

D O I：

10.1080/10406638.2020.1852587

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nowadays heterocyclic compounds containing pyrimidine scaffold attract the interest of many organic chemists due to their strong biological activity, so herein we present the synthesis of new polycyclic compounds starting from 4-chloro-9-phenyl-N-(p-tolyl)pyrimido[5',4':4,5]thieno[3,2-d][1,2,3]triazin-7-amine (1) which allowed to react with hydrazine hydrate to give hydrazinyl triazine compound (2) which subjected to some ring closure reactions using various reagents represented in triethyl orthoformate, acetyl acetone, and carbon disulfide to give compounds (3-5), respectively. Also, when the hydrazinyl compound was allowed to react with acetophenone, ethoxymethylene ethylcyano acetate, and diethyl malonate gave the derivatives (9-11), respectively. The structures of all newly synthesized compounds were confirmed using spectral analysis techniques as well as elemental analysis. Besides, four new compounds were screened for their antimicrobial activity using different strains of bacteria and fungi, and compound 5 displayed the best antimicrobial activity among all the tested compounds.

引用

页码：3079 / 3088

页数：10

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