Unveiling the presence of biosynthetic pathways for bioactive compounds in the Thalassiosira rotula transcriptome

被引：22

作者：

Di Dato, Valeria ^{[1
]}

Di Costanzo, Federica ^{[1
]}

Barbarinaldi, Roberta ^{[1
]}

Perna, Anna ^{[1
]}

Ianora, Adrianna ^{[1
]}

Romano, Giovanna ^{[1
]}

机构：

[1] Stn Zool Anton Dohrn Napoli, Dept Marine Biotechnol, I-80121 Naples, Italy

来源：

SCIENTIFIC REPORTS | 2019年 / 9卷 / 1期

基金：

欧盟地平线“2020”;

关键词：

POLYKETIDE SYNTHASES; NONRIBOSOMAL PEPTIDE; PROSTAGLANDINS; ANNOTATION; ACID; TOOL; TRANSPORTERS; GENOMICS; INSIGHTS; PROGRAM;

D O I：

10.1038/s41598-019-46276-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Diatoms are phytoplankton eukaryotic microalgae that are widely distributed in the world's oceans and are responsible for 20-25% of total carbon fixation on the planet. Using transcriptome sequencing here we show for the first time that the ubiquitous diatom Thalassiosira rotula expresses biosynthetic pathways that potentially lead to the synthesis of interesting secondary metabolites with pharmaceutical applications such as polyketides, prostaglandins and secologanin. We also show that these pathways are differentially expressed in conditions of silica depletion in comparison with standard growth conditions.

引用

页数：14

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