Mothers of Preterm Infants Have Individualized Breast Milk Microbiota that Changes Temporally Based on Maternal Characteristics

被引：36

作者：

Asbury, Michelle R. ^{[1
,2
]}

Butcher, James ^{[3
,4
]}

Copeland, Julia K. ^{[5
]}

Unger, Sharon ^{[1
,6
,7
,8
]}

Bando, Nicole ^{[2
]}

Comelli, Elena M. ^{[1
,9
]}

Forte, Victoria ^{[1
,2
]}

Kiss, Alex ^{[10
,11
]}

LeMay-Nedjelski, Lauren ^{[1
,2
]}

Sherman, Philip M. ^{[1
,12
,13
]}

Stintzi, Alain ^{[3
,4
]}

Tomlinson, Christopher ^{[1
,2
,8
]}

Wang, Pauline W. ^{[5
]}

O'Connor, Deborah L. ^{[1
,2
,6
,7
]}

机构：

[1] Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON M5S 1A8, Canada

[2] Hosp Sick Children, Translat Med Program, Toronto, ON M5G 0A4, Canada

[3] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada

[4] Univ Ottawa, Ottawa Inst Syst Biol, Ottawa, ON K1H 8M5, Canada

[5] Univ Toronto, Ctr Anal Genome Evolut & Funct, Toronto, ON M5S 3B2, Canada

[6] Sinai Hlth, Rogers Hixon Ontario Human Milk Bank, Toronto, ON M5G 1X5, Canada

[7] Sinai Hlth, Dept Pediat, Toronto, ON M5G 1X5, Canada

[8] Hosp Sick Children, Div Neonatol, Toronto, ON M5G 1X8, Canada

[9] Univ Toronto, Joannah & Brian Lawson Ctr Child Nutr, Toronto, ON M5S 1A8, Canada

[10] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON M5T 3M6, Canada

[11] Sunnybrook Res Inst, Evaluat & Clin Sci, Toronto, ON M4N 3M5, Canada

[12] Hosp Sick Children, Cell Biol Program, Toronto, ON M5G 0A4, Canada

[13] Hosp Sick Children, Gastroenterol Hepatol & Nutr, Toronto, ON M5G 1X8, Canada

来源：

CELL HOST & MICROBE | 2020年 / 28卷 / 05期

基金：

加拿大健康研究院;

关键词：

GUT MICROBIOTA; DELIVERY MODE; WEIGHT; HEALTHY; SEQUENCES; IMPACT;

D O I：

10.1016/j.chom.2020.08.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mother's milk contains complex microbial communities thought to be important for colonizing a preterm infant's gastrointestinal tract. However, little is known about the microbiota in the preterm mother's milk and factors influencing its composition, We characterized the temporal dynamics of microbial communities in 490 breast milk samples from 86 mothers of preterm infants (born <1,250g) over the first 8 weeks postpartum. Highly individualized microbial communities were identified in each mother's milk that changed temporally with notable alterations in predicted microbial functions. However, pre-pregnancy BMI, delivery mode, and antibiotics were associated with changes in these microbial dynamics. Individual classes of an- tibiotics and their duration of exposure during prenatal and postpartum periods showed unique relationships with microbial taxa abundance and diversity in mother's milk. These results highlight the temporal complexity of the preterm mother's milk microbiota and its relationship with maternal characteristics as well as the importance of discussing antibiotic stewardship for mothers.

引用

页码：669 / +

页数：18

共 94 条

[91] Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure [J].