S Marks the Spot: Linking the Antioxidant Activity of N-Acetyl Cysteine to H2S and Sulfane Sulfur Species

被引：8
作者：
Cerda, Matthew M. [1 ,2 ,3 ]
Pluth, Michael D. [1 ,2 ,3 ]
机构：
[1] Univ Oregon, Dept Chem & Biochem, Eugene, OR 97403 USA
[2] Univ Oregon, Inst Mol Biol, Eugene, OR 97403 USA
[3] Univ Oregon, Inst Mat Sci, Eugene, OR 97403 USA
来源：
CELL CHEMICAL BIOLOGY | 2018年 / 25卷 / 04期
基金：
美国国家科学基金会;
关键词：
HYDROGEN-SULFIDE; CHEMICAL BIOLOGY;
D O I：
10.1016/j.chembiol.2018.04.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
N-Acetyl cysteine (NAC) is commonly used as an antioxidant and cytoprotectant, yet a broadly applicable mechanism of these activities has remained elusive. In this issue of Cell Chemical Biology, Ezerina et al. (2018) report an alternative mechanism for NAC cytoprotection and antioxidant activity by demonstrating that NAC treatment increases sulfane sulfur production via intermediate H2S generation.
引用
收藏
页码：353 / 355
页数：3
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