TP53 Mutations and Lung Cancer: Not All Mutations Are Created Equal

被引：26

作者：

Govindan, Ramaswamy ^{[1
,2
]}

Weber, Jason ^{[1
,2
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[2] Washington Univ, Alvin J Siteman Canc Ctr, St Louis, MO 63110 USA

来源：

CLINICAL CANCER RESEARCH | 2014年 / 20卷 / 17期

关键词：

P53; MUTATIONS; MUTANT P53; SURVIVAL; CARCINOMA; RAS;

D O I：

10.1158/1078-0432.CCR-14-0899

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mutations in TP53 are common in non-small cell lung cancer. Apart from the loss of tumor-suppressor functions, TP53 mutations may result in gain of function favoring cellular proliferation, inhibition of apoptosis, and genomic instability. Some TP53 mutations are more likely to affect the course of the disease than others. (C) 2014 AACR.

引用

页码：4419 / 4421

页数：3

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