Type 2 Diabetes: Is Pancreas Transplantation an Option?

被引：15
作者：
Ciancio, Gaetano [1 ,2 ,3 ,4 ,6 ]
Burke, George W. [1 ,2 ,3 ,4 ,5 ,6 ]
机构：
[1] Univ Miami, Miller Sch Med, DeWitt Daughtry Family Dept Surg, Miami, FL 33101 USA
[2] Univ Miami, Miller Sch Med, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
[3] Univ Miami, Miller Sch Med, Div Transplantat, Miami, FL 33101 USA
[4] Univ Miami, Miller Sch Med, Miami Transplant Inst, Miami, FL 33101 USA
[5] Univ Miami, Miller Sch Med, Diabet Res Inst, Miami, FL 33101 USA
[6] Univ Miami, Miller Sch Med, Div Transplantat, Dept Surg, Miami, FL 33101 USA
来源：
CURRENT DIABETES REPORTS | 2014年 / 14卷 / 11期
关键词：
Pancreas transplantation; Type 2 diabetes mellitus; C-peptide; Patient candidates; Type 1 diabetes mellitus; KIDNEY TRANSPLANTATION; C-PEPTIDE; MYCOPHENOLATE-MOFETIL; TACROLIMUS; OUTCOMES; NEPHROPATHY; RETINOPATHY; RECIPIENTS; DISEASE; LESIONS;
D O I：
10.1007/s11892-014-0542-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Transplantation of the whole vascularized pancreas can provide insulin secretion in patients with insulin-dependent, type 1 diabetes mellitus (T1D). It restores euglycemia in most patients, with the potential to impact the chronic diabetic complications and quality of life. Pancreas transplantation (PT) is presently controversial for type 2 diabetes mellitus (T2D). For those patients with severe glycemic dysregulation, T2D can be associated with the same life-threatening sequelae as T1D such as severe hypoglycemia and kidney failure that could be corrected by pancreas (and kidney) transplantation. Thus, clinical indications and patient selection criteria are very important. This chapter will review the current status of PT for T2D and discuss the options and evolution of transplant perspectives.
引用
收藏
页数：6
相关论文
共 37 条
[1]  
Burke George W. Iii, 1997, P1311
[2]   Advances in pancreas transplantation [J].
Burke, GW ;
Ciancio, G ;
Sollinger, HW .
TRANSPLANTATION, 2004, 77 (09) :S62-S67
[3]   Ten-year survival after simultaneous pancreas/kidney transplantation with bladder drainage and tacrolimus-based immunosuppression [J].
Burke, GW ;
Ciancio, G ;
Olson, L ;
Roth, D ;
Miller, J .
TRANSPLANTATION PROCEEDINGS, 2001, 33 (1-2) :1681-1683
[4]   Advantage of Rapamycin Over Mycophenolate Mofetil When Used With Tacrolimus for Simultaneous Pancreas Kidney Transplants: Randomized, Single-Center Trial at 10 Years [J].
Ciancio, G. ;
Sageshima, J. ;
Chen, L. ;
Gaynor, J. J. ;
Hanson, L. ;
Tueros, L. ;
Montenora-Velarde, E. ;
Gomez, C. ;
Kupin, W. ;
Guerra, G. ;
Mattiazzi, A. ;
Fornoni, A. ;
Pugliese, A. ;
Roth, D. ;
Wolf, M. ;
Burke, G. W., III .
AMERICAN JOURNAL OF TRANSPLANTATION, 2012, 12 (12) :3363-3376
[5]   The use of daclizumab as induction therapy in combination with tacrolimus and mycophenolate mofetil in recipients with previous transplants [J].
Ciancio, G ;
Mattiazzi, A ;
Roth, D ;
Kupin, W ;
Miller, J ;
Burke, GW .
CLINICAL TRANSPLANTATION, 2003, 17 (05) :428-432
[6]  
Ciancio G, 2000, Expert Opin Pharmacother, V1, P1307, DOI 10.1517/14656566.1.7.1307
[7]   The beneficial effects of pancreas transplant alone on diabetic nephropathy [J].
Coppelli, A ;
Rizzo, G ;
Giannarelli, R ;
Mosca, F ;
Vistoli, F ;
Boggi, U ;
Del Prato, S ;
Marchetti, P .
DIABETES CARE, 2005, 28 (06) :1366-1370
[8]   Posttransplant diabetes mellitus after pancreas transplantation [J].
Dean, P. G. ;
Kudva, Y. C. ;
Larson, T. S. ;
Kremers, W. K. ;
Stegall, M. D. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2008, 8 (01) :175-182
[9]   The utility of the C-peptide in the phenotyping of patients candidates for pancreas transplantation [J].
Esmatjes, Enric ;
Fernandez, Cristian ;
Rueda, Sergio ;
Nicolau, Juana ;
Chiganer, Gaston ;
Jose Ricart, Maria ;
Junca, Elizabet ;
Fernandez-Cruz, Laureano .
CLINICAL TRANSPLANTATION, 2007, 21 (03) :358-362
[10]   Obesity, bariatric surgery and type2 diabetes - a systematic review [J].
Ferchak, CV ;
Meneghini, LF .
DIABETES-METABOLISM RESEARCH AND REVIEWS, 2004, 20 (06) :438-445
1234