Combined systemic administration of morphine and magnesium sulfate attenuates pain-related behavior in mononeuropathic rats

被引：29

作者：

Ulugol, A ^{[1
]}

Aslantas, A ^{[1
]}

Ipci, Y ^{[1
]}

Tuncer, A ^{[1
]}

Karadag, CH ^{[1
]}

Dokmeci, I ^{[1
]}

机构：

[1] Trakya Univ, Fac Med, Dept Pharmacol, TR-22030 Edirne, Turkey

来源：

BRAIN RESEARCH | 2002年 / 943卷 / 01期

关键词：

neuropathic pain; allodynia; morphine; magnesium;

D O I：

10.1016/S0006-8993(02)02618-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The response to opioids is reduced in neuropathic pain states. We examined the effect of the combination of morphine (0.1 mg/kg) and magnesium sulfate (125 mg/kg) on behavioral signs of neuropathic pain in spinal nerve ligated rats. Administered alone, neither drug produced any effect, but the combination exerted a significant anti-allodynic effect, which was partially reversed by naloxone. These results suggest that combining low doses of magnesium sulfate with opiates might be an alternative in treating neuropathic pain, with reduced risk of side effects. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：101 / 104

页数：4

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