Structure and regulated expression of mammalian RUNX genes

被引：242
作者：
Levanon, D [1 ]
Groner, Y [1 ]
机构：
[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel
来源：
ONCOGENE | 2004年 / 23卷 / 24期
基金：
以色列科学基金会;
关键词：
gene structure; promoter analysis; translation control; signaling pathways; tissue-specific expression;
D O I：
10.1038/sj.onc.1207670
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The RUNX are key regulators of lineage-specific gene expression in major developmental pathways. The expression of RUNX genes is tightly regulated, leading to a highly specific spatio/temporal expression pattern and to distinct phenotypes of gene knockouts. This review highlights the extensive structural similarities between the three mammalian RUNX genes and delineates how regulation of their expression at the levels of transcription and translation are orchestrated into the unique RUNX expression pattern.
引用
收藏
页码：4211 / 4219
页数：9
相关论文
共 128 条
[51]   Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts [J].
Komori, T ;
Yagi, H ;
Nomura, S ;
Yamaguchi, A ;
Sasaki, K ;
Deguchi, K ;
Shimizu, Y ;
Bronson, RT ;
Gao, YH ;
Inada, M ;
Sato, M ;
Okamoto, R ;
Kitamura, Y ;
Yoshiki, S ;
Kishimoto, T .
CELL, 1997, 89 (05) :755-764
[52]   Cbfβ interacts with Runx2 and has a critical role in bone development [J].
Kundu, M ;
Javed, A ;
Jeon, JP ;
Horner, A ;
Shum, L ;
Eckhaus, M ;
Muenke, M ;
Lian, JB ;
Yang, YZ ;
Nuckolls, GH ;
Stein, GS ;
Liu, PP .
NATURE GENETICS, 2002, 32 (04) :639-644
[53]   Regulation of AML2/CBFA3 in hematopoietic cells through the retinoic acid receptor α-dependent signaling pathway [J].
Le, XF ;
Groner, Y ;
Kornblau, SM ;
Gu, Y ;
Hittelman, WN ;
Levanon, D ;
Mehta, K ;
Arlinghaus, RB ;
Chang, KS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (31) :21651-21658
[54]   A serrate-expressing signaling center controls Drosophila hematopoiesis [J].
Lebestky, T ;
Jung, SH ;
Banerjee, U .
GENES & DEVELOPMENT, 2003, 17 (03) :348-353
[55]   Specification of Drosophila hematopoietic lineage by conserved transcription factors [J].
Lebestky, T ;
Chang, T ;
Hartenstein, V ;
Banerjee, U .
SCIENCE, 2000, 288 (5463) :146-149
[56]  
Lecka-Czernik B, 1999, J CELL BIOCHEM, V74, P357, DOI 10.1002/(SICI)1097-4644(19990901)74:3<357::AID-JCB5>3.0.CO
[57]  
2-7
[58]   Runx2 is a common target of transforming growth factor β1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12 [J].
Lee, KS ;
Kim, HJ ;
Li, QL ;
Chi, XZ ;
Ueta, C ;
Komori, T ;
Wozney, JM ;
Kim, EG ;
Choi, JY ;
Ryoo, HM ;
Bae, SC .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (23) :8783-8792
[59]   Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-β and bone morphogenetic protein [J].
Lee, KS ;
Hong, SH ;
Bae, SC .
ONCOGENE, 2002, 21 (47) :7156-7163
[60]  
Lee MH, 1999, J CELL BIOCHEM, V73, P114, DOI 10.1002/(SICI)1097-4644(19990401)73:1<114::AID-JCB13>3.3.CO
12345678910