Structure and regulated expression of mammalian RUNX genes

被引：242
作者：
Levanon, D [1 ]
Groner, Y [1 ]
机构：
[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel
来源：
ONCOGENE | 2004年 / 23卷 / 24期
基金：
以色列科学基金会;
关键词：
gene structure; promoter analysis; translation control; signaling pathways; tissue-specific expression;
D O I：
10.1038/sj.onc.1207670
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The RUNX are key regulators of lineage-specific gene expression in major developmental pathways. The expression of RUNX genes is tightly regulated, leading to a highly specific spatio/temporal expression pattern and to distinct phenotypes of gene knockouts. This review highlights the extensive structural similarities between the three mammalian RUNX genes and delineates how regulation of their expression at the levels of transcription and translation are orchestrated into the unique RUNX expression pattern.
引用
收藏
页码：4211 / 4219
页数：9
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