Structure and regulated expression of mammalian RUNX genes

被引：240
作者：
Levanon, D [1 ]
Groner, Y [1 ]
机构：
[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel
来源：
ONCOGENE | 2004年 / 23卷 / 24期
基金：
以色列科学基金会;
关键词：
gene structure; promoter analysis; translation control; signaling pathways; tissue-specific expression;
D O I：
10.1038/sj.onc.1207670
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The RUNX are key regulators of lineage-specific gene expression in major developmental pathways. The expression of RUNX genes is tightly regulated, leading to a highly specific spatio/temporal expression pattern and to distinct phenotypes of gene knockouts. This review highlights the extensive structural similarities between the three mammalian RUNX genes and delineates how regulation of their expression at the levels of transcription and translation are orchestrated into the unique RUNX expression pattern.
引用
收藏
页码：4211 / 4219
页数：9
相关论文
共 128 条
[1]   TGF-β-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation [J].
Alliston, T ;
Choy, L ;
Ducy, P ;
Karsenty, G ;
Derynck, R .
EMBO JOURNAL, 2001, 20 (09) :2254-2272
[2]   MAPPING OF THE MOUSE HOMOLOG OF THE HUMAN RUNT DOMAIN GENE, AML2, TO THE DISTAL REGION OF MOUSE CHROMOSOME-4 [J].
AVRAHAM, KB ;
LEVANON, D ;
NEGREANU, V ;
BERNSTEIN, Y ;
GRONER, Y ;
COPELAND, NG ;
JENKINS, NA .
GENOMICS, 1995, 25 (02) :603-605
[3]   CLONING, MAPPING AND EXPRESSION OF PEBP2-ALPHA-C, A 3RD GENE ENCODING THE MAMMALIAN RUNT DOMAIN [J].
BAE, SC ;
TAKAHASHI, E ;
ZHANG, YW ;
OGAWA, E ;
SHIGESADA, K ;
NAMBA, Y ;
SATAKE, M ;
ITO, Y .
GENE, 1995, 159 (02) :245-248
[4]   PEBP2-ALPHA-B/MOUSE AML1 CONSISTS OF MULTIPLE ISOFORMS THAT POSSESS DIFFERENTIAL TRANSACTIVATION POTENTIALS [J].
BAE, SC ;
OGAWA, E ;
MARUYAMA, M ;
OKA, H ;
SATAKE, M ;
SHIGESADA, K ;
JENKINS, NA ;
GILBERT, DJ ;
COPELAND, NG ;
ITO, Y .
MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (05) :3242-3252
[5]   cDNA cloning of run, a Caenorhabditis elegans Runt domain encoding gene [J].
Bae, SC ;
Lee, J .
GENE, 2000, 241 (02) :255-258
[6]   Differential regulation of the two principal Runx2/Cbfa1 N-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype [J].
Banerjee, C ;
Javed, A ;
Choi, JY ;
Green, J ;
Rosen, V ;
van Wijnen, AJ ;
Stein, JL ;
Lian, JB ;
Stein, GS .
ENDOCRINOLOGY, 2001, 142 (09) :4026-4039
[7]   The RUNX3 gene -: sequence, structure and regulated expression [J].
Bangsow, C ;
Rubins, N ;
Glusman, G ;
Bernstein, Y ;
Negreanu, V ;
Goldenberg, D ;
Lotem, J ;
Ben-Asher, E ;
Lancet, D ;
Levanon, D ;
Groner, Y .
GENE, 2001, 279 (02) :221-232
[8]   Expression of AML1-d, a short human AML1 isoform, in embryonic stem cells suppresses in vivo tumor growth and differentiation [J].
Ben Aziz-Aloya, R ;
Levanon, D ;
Karn, H ;
Kidron, D ;
Goldenberg, D ;
Lotem, J ;
Polak-Chaklon, S ;
Groner, Y .
CELL DEATH AND DIFFERENTIATION, 1998, 5 (09) :765-773
[9]   ROLE OF ACTIVE AND LATENT TRANSFORMING GROWTH-FACTOR-BETA IN BONE-FORMATION [J].
BONEWALD, LF ;
DALLAS, SL .
JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, 55 (03) :350-357
[10]   Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo [J].
Cai, ZL ;
de Bruijn, M ;
Ma, XQ ;
Dortland, B ;
Luteijn, T ;
Downing, JR ;
Dzierzak, E .
IMMUNITY, 2000, 13 (04) :423-431
12345678910