The Role of Long Noncoding RNAs in the Epigenetic Control of Gene Expression

被引：69

作者：

Morlando, Mariangela ^{[1
,2
]}

Ballarino, Monica ^{[1
,2
]}

Fatica, Alessandro ^{[1
,2
]}

Bozzoni, Irene ^{[1
,2
,3
,4
]}

机构：

[1] Univ Roma La Sapienza, Dept Biol & Biotechnol Charles Darwin, I-00185 Rome, Italy

[2] Univ Roma La Sapienza, Inst Mol Biol & Pathol IBPM, I-00185 Rome, Italy

[3] Italian Inst Technol IIT, Ctr Life Nano Sci Sapienza, I-00161 Rome, Italy

[4] Univ Roma La Sapienza, Inst Pasteur, Fdn Cenci Bolognetti, I-00185 Rome, Italy

来源：

CHEMMEDCHEM | 2014年 / 9卷 / 03期

关键词：

chromatin; epigenetics; histones; long noncoding RNA; modular scaffolds; HISTONE METHYLTRANSFERASE ACTIVITY; GENOME REGULATION; GROUP PROTEINS; POLYCOMB; CHROMATIN; TRANSCRIPTION; HETEROCHROMATIN; METHYLATION; ENHANCER; COMPLEX;

D O I：

10.1002/cmdc.201300569

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Recent advances in the methodologies employed to deeply analyse the complexity of transcriptomes have unveiled the existence of a new class of transcripts, long noncoding RNAs (lncRNAs). A significant amount of effort has been dedicated to the study of lncRNAs, and a large body of evidence now exists indicating their relevant role in different regulatory steps of gene expression. Given the role of epigenetics in disease development and progression, this Minireview focuses on lncRNAs involved in epigenetic control and provides an overview of the mechanisms used to guide epigenetic-modifying complexes to adjacent (cis-acting) or independent (trans-acting) genomic loci. Furthermore, it describes the activities of these transcripts in controlling the formation and spreading of heterochromatin domains. Just as other RNA molecules have found therapeutic application, though much remains to be elucidated about the structure and function of these lncRNAs, they too could hold potential as biomarkers, targets, and therapeutic agents.

引用

页码：505 / 510

页数：6

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