Membrane Interaction and Functional Plasticity of Inositol Polyphosphate 5-Phosphatases

被引：8
作者：
Braun, Werner [1 ,2 ]
Schein, Catherine H. [3 ]
机构：
[1] Univ Texas Med Branch, Sealy Ctr Struct Biol & Mol Biophys, Galveston, TX 77555 USA
[2] Univ Texas Med Branch, Dept Biochem & Mol Biol, Galveston, TX 77555 USA
[3] Fdn Appl Mol Evolut, Gainesville, FL 32601 USA
来源：
STRUCTURE | 2014年 / 22卷 / 05期
关键词：
DNA-REPAIR; ENDONUCLEASES; SPECIFICITY; CATALYSIS; MECHANISM; BINDING; APE1;
D O I：
10.1016/j.str.2014.04.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this issue of Structure, Tresaugues and colleagues determined the interaction of membrane-bound phosphoinositides with three clinically significant human inositol polyphosphate 5-phosphatases (I5Ps). A comparison to the structures determined with soluble substrates revealed differences in the binding mode and suggested how the I5Ps and apurinic endonuclease (APE1) activities evolved from the same metal-binding active center.
引用
收藏
页码：664 / 666
页数：4
相关论文
共 14 条
  • [1] Effect of ionic strength and oxidation on the P-loop conformation of the protein tyrosine phosphatase-like phytase, PhyAsr
    Gruninger, Robert J.
    Selinger, L. Brent
    Mosimann, Steven C.
    [J]. FEBS JOURNAL, 2008, 275 (15) : 3783 - 3792
  • [2] Mobile loop mutations in an archaeal inositol monophosphatase: Modulating three-metal ion assisted catalysis and lithium inhibition
    Li, Zheng
    Stieglitz, Kimberly A.
    Shrout, Anthony L.
    Wei, Yang
    Weis, Robert M.
    Stec, Boguslaw
    Roberts, Mary F.
    [J]. PROTEIN SCIENCE, 2010, 19 (02) : 309 - 318
  • [3] Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain
    Lupardus, Patrick J.
    Shen, Aimee
    Bogyo, Matthew
    Garcia, K. Christopher
    [J]. SCIENCE, 2008, 322 (5899) : 265 - 268
  • [4] Identifying property based sequence motifs in protein families and superfamilies: application to DNase-1 related endonucleases
    Mathura, VS
    Schein, CH
    Braun, W
    [J]. BIOINFORMATICS, 2003, 19 (11) : 1381 - 1390
  • [5] DNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination
    Mol, CD
    Izumi, T
    Mitra, S
    Tainer, JA
    [J]. NATURE, 2000, 403 (6768) : 451 - 456
  • [6] A "moving metal mechanism" for substrate cleavage by the DNA repair endonuclease APE-1
    Oezguen, Numan
    Schein, Catherine H.
    Peddi, Srinivasa R.
    Power, Evor D.
    Izumi, Tadahide
    Braun, Werner
    [J]. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2007, 68 (01) : 313 - 323
  • [7] Oezguen N, 2011, BIOINFORMATION, V7, P184
  • [8] Structure-Function Analysis of Inositol Hexakisphosphate-induced Autoprocessing in Clostridium difficile Toxin A
    Pruitt, Rory N.
    Chagot, Benjamin
    Cover, Michael
    Chazin, Walter J.
    Spiller, Ben
    Lacy, D. Borden
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (33) : 21934 - 21940
  • [9] Molego-based definition of the architecture and specificity of metal-binding sites
    Schein, CH
    Zhou, B
    Oezguen, N
    Mathura, VS
    Braun, W
    [J]. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2005, 58 (01) : 200 - 210
  • [10] Total sequence decomposition distinguishes functional modules, "molegos" in apurinic/apyrimidinic endonucleases -: art. no. 37
    Schein, CH
    Özgün, N
    Izumi, T
    Braun, W
    [J]. BMC BIOINFORMATICS, 2002, 3 (1)
12