Licensing of DNA replication, cancer, pluripotency and differentiation: An interlinked world?

被引：66
作者：
Tsaniras, S. Champeris [1 ]
Kanellakis, N. [1 ]
Symeonidou, I. E. [2 ]
Nikolopoulou, P. [1 ]
Lygerou, Z. [2 ]
Taraviras, S. [1 ]
机构：
[1] Univ Patras, Sch Med, Dept Physiol, Patras 26504, Greece
[2] Univ Patras, Sch Med, Dept Biol, Patras 26504, Greece
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2014年 / 30卷
关键词：
DNA replication; Licensing; Origin specification; Cancer; Pluripotency; Development; ORIGIN RECOGNITION COMPLEX; EMBRYONIC STEM-CELLS; MEIER-GORLIN SYNDROME; CHROMATIN REMODELING COMPLEX; ACUTE MYELOID-LEUKEMIA; GENOME-WIDE; SYNTHETASE-ACTIVITY; BREAST-CANCER; C-MYC; TRANSCRIPTIONAL CONTROL;
D O I：
10.1016/j.semcdb.2014.03.013
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Recent findings provide evidence for a functional interplay between DNA replication and the seemingly distinct areas of cancer, development and pluripotency. Protein complexes participating in DNA replication origin licensing are now known to have roles in development, while their deregulation can lead to cancer. Moreover, transcription factors implicated in the maintenance of or reversal to the pluripotent state have links to the pre-replicative machinery. Several studies have shown that overexpression of these factors is associated to cancer. (C) 2014 The Authors. Published by Elsevier Ltd.
引用
收藏
页码：174 / 180
页数：7
相关论文
共 137 条
[1]   Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence [J].
Agherbi, Hanane ;
Gaussmann-Wenger, Anne ;
Verthuy, Christophe ;
Chasson, Lionel ;
Serrano, Manuel ;
Djabali, Malek .
PLOS ONE, 2009, 4 (05)
[2]   A small gem with great Powers: Geminin keeps neural progenitors thriving [J].
Aigner, S ;
Gage, FH .
DEVELOPMENTAL CELL, 2005, 9 (02) :171-172
[3]   The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a [J].
Becker, Therese M. ;
Haferkamp, Sebastian ;
Dijkstra, Menno K. ;
Scurr, Lyndee L. ;
Frausto, Monika ;
Diefenbach, Eve ;
Scolyer, Richard A. ;
Reisman, David N. ;
Mann, Graham J. ;
Kefford, Richard F. ;
Rizos, Helen .
MOLECULAR CANCER, 2009, 8
[4]   Mutations in the pre-replication complex cause Meier-Gorlin syndrome [J].
Bicknell, Louise S. ;
Bongers, Ernie M. H. F. ;
Leitch, Andrea ;
Brown, Stephen ;
Schoots, Jeroen ;
Harley, Margaret E. ;
Aftimos, Salim ;
Al-Aama, Jumana Y. ;
Bober, Michael ;
Brown, Paul A. J. ;
van Bokhoven, Hans ;
Dean, John ;
Edrees, Alaa Y. ;
Feingold, Murray ;
Fryer, Alan ;
Hoefsloot, Lies H. ;
Kau, Nikolaus ;
Knoers, Nine V. A. M. ;
MacKenzie, James ;
Opitz, John M. ;
Sarda, Pierre ;
Ross, Alison ;
Temple, I. Karen ;
Toutain, Annick ;
Wise, Carol A. ;
Wright, Michael ;
Jackson, Andrew P. .
NATURE GENETICS, 2011, 43 (04) :356-+
[5]   Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome [J].
Bicknell, Louise S. ;
Walker, Sarah ;
Klingseisen, Anna ;
Stiff, Tom ;
Leitch, Andrea ;
Kerzendorfer, Claudia ;
Martin, Carol-Anne ;
Yeyati, Patricia ;
Al Sanna, Nouriya ;
Bober, Michael ;
Johnson, Diana ;
Wise, Carol ;
Jackson, Andrew P. ;
O'Driscoll, Mark ;
Jeggo, Penny A. .
NATURE GENETICS, 2011, 43 (04) :350-U103
[6]   Preventing re-replication of chromosomal DNA [J].
Blow, JJ ;
Dutta, A .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (06) :476-486
[7]   Polycomb group proteins: navigators of lineage pathways led astray in cancer [J].
Bracken, Adrian P. ;
Helin, Kristian .
NATURE REVIEWS CANCER, 2009, 9 (11) :773-784
[8]  
Bravou V, 2005, INT J ONCOL, V27, P1511
[9]   Bmi1 controls tumor development in an ink4a/Arf-independent manner in a mouse model for glioma [J].
Bruggeman, Sophia W. M. ;
Hulsman, Danielle ;
Tanger, Ellen ;
Buckle, Tessa ;
Blom, Marleen ;
Zevenhoven, John ;
van Tellingen, Olaf ;
van Lohuizen, Maarten .
CANCER CELL, 2007, 12 (04) :328-341
[10]   Genome-wide studies highlight indirect links between human replication origins and gene regulation [J].
Cadoret, Jean-Charles ;
Meisch, Francoise ;
Hassan-Zadeh, Vahideh ;
Luyten, Isabelle ;
Guillet, Claire ;
Duret, Laurent ;
Quesneville, Hadi ;
Prioleau, Marie-Noelle .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (41) :15837-15842
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