Prins Cascade Cyclization for the Synthesis of 1,9-Dioxa-4-azaspiro[5.5]undecane Derivatives

被引：28

作者：

Reddy, B. V. Subba ^{[1
]}

Medaboina, Durgaprasad ^{[1
]}

Sridhar, B. ^{[2
]}

Singarapu, Kiran Kumar ^{[3
]}

机构：

[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Lab Xray Crystallog, Hyderabad 500007, Andhra Pradesh, India

[3] Indian Inst Chem Technol, Ctr Nucl Magnet Resonance, Hyderabad 500007, Andhra Pradesh, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 05期

关键词：

STEREOSELECTIVE-SYNTHESIS; NK1; ANTAGONISTS; BICYCLES; POTENT; SYSTEM;

D O I：

10.1021/jo4027534

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel Prins cascade process for the synthesis of 1,9-dioxa-4- azaspiro[5.5]undecane derivatives by the coupling of aldehydes with N-(4-hydroxy-2-methylenebutyl)-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide has been developed. This is the first report of the synthesis of spiromorpholinotetrahydropyran derivatives through a Prins bicyclization.

引用

页码：2289 / 2295

页数：7

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