Copper-catalyzed alkyne-aryne coupling reaction under microwave conditions: preparation of unsymmetric and symmetric di-substituted alkynes

被引：12

作者：

Akubathini, Shashidhar Kumar ^{[1
]}

Biehl, Ed ^{[1
]}

机构：

[1] So Methodist Univ, Dept Chem, Dallas, TX 75275 USA

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 16期

关键词：

Benzyne; Copper-catalyzed; Alkyne-aryne coupling; Microwave-assisted reactions; ONE-POT SYNTHESIS; IRRADIATION; BENZYNE;

D O I：

10.1016/j.tetlet.2009.02.033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several unsymmetric and symmetric alkynes were prepared excellent to modest yields by generating benzyne from the reaction of 2-(trimethylsilyl)phenyl triflate with CsF in the presence of Cul and terminal alkyne under microwave heating for 30 min at 150 degrees C. Using conventional heating, the reactions required 24 h reaction time. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1809 / 1811

页数：3

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