Phosphoinositide 3-kinase: the protein kinase that time forgot

被引：13

作者：

Foukas, LC

Shepherd, PR

机构：

[1] Ludwig Inst Canc Res, London W1W 7BS, England

[2] UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2004年 / 32卷

关键词：

phosphoinositide; 3-kinase; phosphorylation; protein kinase; signalling;

D O I：

10.1042/BST0320330

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Class I phosphoinositicle 3-kinases were originally characterized as lipid kinases, although more than 10 years ago they were also found to phosphorylate protein serine residues. However, while there is a vast amount of data on the function of this lipid kinase activity, relatively little is known about the function of the protein kinase activity. We discuss the evidence that suggests that the protein kinase activity of phosphoinositicle 3-kinases mediates important signalling functions in cells.

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收藏

页码：330 / 331

页数：2

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