Phosphoinositide 3-kinase: the protein kinase that time forgot

被引：13

作者：

Foukas, LC

Shepherd, PR

机构：

[1] Ludwig Inst Canc Res, London W1W 7BS, England

[2] UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2004年 / 32卷

关键词：

phosphoinositide; 3-kinase; phosphorylation; protein kinase; signalling;

D O I：

10.1042/BST0320330

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Class I phosphoinositicle 3-kinases were originally characterized as lipid kinases, although more than 10 years ago they were also found to phosphorylate protein serine residues. However, while there is a vast amount of data on the function of this lipid kinase activity, relatively little is known about the function of the protein kinase activity. We discuss the evidence that suggests that the protein kinase activity of phosphoinositicle 3-kinases mediates important signalling functions in cells.

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收藏

页码：330 / 331

页数：2

相关论文

共 19 条

[1] Comparison of the kinetic properties of the lipid- and protein-kinase activities of the p110α and p110β catalytic subunits of class-Ia phosphoinositide 3-kinases [J].

Beeton, CA ;

Chance, EM ;

Foukas, LC ;

Shepherd, PR .

BIOCHEMICAL JOURNAL, 2000, 350 :353-359

[2] Bifurcation of lipid and protein kinase signals of PI3Kγ to the protein kinases PKB and MAPK [J].

Bondeva, T ;

Pirola, L ;

Bulgarelli-Leva, G ;

Rubio, I ;

Wetzker, R ;

Wymann, MP .

SCIENCE, 1998, 282 (5387) :293-296

[3] The phosphoinositide 3-kinase pathway [J].

Cantley, LC .

SCIENCE, 2002, 296 (5573) :1655-1657

[4] A TIGHTLY ASSOCIATED SERINE THREONINE PROTEIN-KINASE REGULATES PHOSPHOINOSITIDE 3-KINASE ACTIVITY [J].

CARPENTER, CL ;

AUGER, KR ;

DUCKWORTH, BC ;

HOU, WM ;

SCHAFFHAUSEN, B ;

CANTLEY, LC .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (03) :1657-1665

[5] Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms β and γ [J].

Czupalla, C ;

Culo, M ;

Müller, EC ;

Brock, C ;

Reusch, HP ;

Spicher, K ;

Krause, E ;

Nürnberg, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (13) :11536-11545

[6] PI-3-KINASE IS A DUAL-SPECIFICITY ENZYME - AUTOREGULATION BY AN INTRINSIC PROTEIN-SERINE KINASE-ACTIVITY [J].

DHAND, R ;

HILES, I ;

PANAYOTOU, G ;

ROCHE, S ;

FRY, MJ ;

GOUT, I ;

TOTTY, NF ;

TRUONG, O ;

VICENDO, P ;

YONEZAWA, K ;

KASUGA, M ;

COURTNEIDGE, SA ;

WATERFIELD, MD .

EMBO JOURNAL, 1994, 13 (03) :522-533

[7] Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo [J].

Foukas, LC ;

Beeton, CA ;

Jensen, J ;

Phillips, WA ;

Shepherd, PR .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (03) :966-975

[8] Direct effects of caffeine and theophylline on p110δ and other phosphoinositide 3-kinases -: Differential effects on lipid kinase and protein kinase activities [J].

Foukas, LC ;

Daniele, N ;

Ktori, C ;

Anderson, KE ;

Jensen, J ;

Shepherd, PR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (40) :37124-37130

[9] THE PI3-KINASE SERINE KINASE PHOSPHORYLATES ITS P85 SUBUNIT AND IRS-1 IN PI3-KINASE IRS-1 COMPLEXES [J].

FREUND, GG ;

WITTIG, JG ;

MOONEY, RA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 206 (01) :272-278

[10] WHEN IS A LIPID KINASE NOT A LIPID KINASE - WHEN IT IS A PROTEIN-KINASE [J].

HUNTER, T .

CELL, 1995, 83 (01) :1-4