One-Pot Synthesis of Triazoloquinazolinones via Copper-Catalyzed Tandem Click and Intramolecular C-H Amidation

A novel and highly efficient copper-catalyzed tandem synthesis of triazoloquinazolinones is explored. The synthetic strategy involves a sequential one-pot click reaction followed by aerobic intramolecular CH amidation. Two distinct and important transformations were carried out in one-pot by employing a single cost-effective copper catalyst. The milder, rapid and ligand-free reaction conditions as well as a broader substrate scope are the salient features of this novel protocol.