Synthesis and Anti-inflammatory Activity of Some 2-(4-Chlorophenyl)-6-(substituted phenyl)-thiazolo[3,2-b][1,2,4]triazoles

The reaction of 5-(4-chlorophenyl)-4H-1,2,4-triazole-3-thiol (1) with different 2-bromo-1-(substituted phenyl)ethanones (2) in the presence of base gave 2-{[5-(4-chlorophenyl)-4H-1,2,4-triazole-3-yl]sulfanyl}-1-(substituted phenyl)ethanones (3) which on cyclization in the presence of polyphosphoric acid yielded a series of fused heterocycles, namely 2-(4-chlorophenyl)-6-(substituted phenyl)-thiazolo[3,2-b [1,2,4]triazoles (4a-l). The structures of all the synthesized compounds were characterized with Fourier-transform infrared, H-1 and C-13 nuclear magnetic resonance, time-of-flight mass spectrometry electrospray + data, and elemental (C, H, N, S) analysis. Compounds 4a-l were tested for anti-inflammatory activity. [GRAPHICS] .