Rapid microwave-assisted solution phase synthesis of substituted 2-pyridone libraries

被引：175
|
作者：
Gorobets, NY [1 ]
Yousefi, BH [1 ]
Belaj, F [1 ]
Kappe, CO [1 ]
机构：
[1] Karl Franzens Univ Graz, Inst Organ Chem, A-8010 Graz, Austria
来源：
TETRAHEDRON | 2004年 / 60卷 / 39期
基金：
奥地利科学基金会;
关键词：
microwave synthesis; multi-component reactions; 2-pyridones; 2-quinolones;
D O I：
10.1016/j.tet.2004.05.100
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-Pyridone and 2-quinolone analogues are well-known biologically active heterocyclic scaffolds. Libraries of 3,5,6-substituted 2-pyridone derivatives are generated by rapid microwave assisted solution phase methods using a one-pot, two-step protocol. The three-component condensation of CH-acidic carbonyl compounds, NN-dimethylformamide dimethylacetal and methylene active nitriles, leads to 2-pyridones and fused analogues in moderate to good overall yields and high purities. The proposed mechanism of this novel multicomponent reaction, structure elucidation of products and intermediates are discussed. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8633 / 8644
页数：12
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