An InSitu Depot for Continuous Evolution of Gaseous H2 Mediated by a Magnesium Passivation/Activation Cycle for Treating Osteoarthritis

被引：75

作者：

Wan, Wei-Lin ^{[1
,2
]}

Lin, Yu-Jung ^{[1
,2
]}

Shih, Po-Chien ^{[1
,2
]}

Bow, Yu-Ru ^{[1
,2
]}

Cui, Qinghua ^{[1
,2
]}

Chang, Yen ^{[3
,4
]}

Chia, Tso ^{[5
]}

Sung, Hsing-Wen ^{[1
,2
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem Engn, Frontier Res Ctr Fundamental & Appl Sci Matters, Hsinchu 30013, Taiwan

[2] Natl Tsing Hua Univ, Inst Biomed Engn, Frontier Res Ctr Fundamental & Appl Sci Matters, Hsinchu 30013, Taiwan

[3] Tzu Chi Univ, Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Hualien 97004, Taiwan

[4] Tzu Chi Univ, Sch Med, Hualien 97004, Taiwan

[5] Natl Taiwan Univ Hosp, Hsinchu Branch, Dept Orthopaed, Hsinchu 30059, Taiwan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 31期

关键词：

hydrogen gas; magnesium; medical gas; osteoarthritis; tissue inflammation; THERAPEUTIC ANTIOXIDANT; HYDROGEN; DELIVERY;

D O I：

10.1002/anie.201806159

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Inflammation is involved in many human pathologies, including osteoarthritis (OA). Hydrogen (H-2) is known to have anti-inflammatory effects; however, the bioavailability of directly administered H-2 gas is typically poor. Herein, a local delivery system that can provide a high therapeutic concentration of gaseous H-2 at inflamed tissues is proposed. The delivery system comprises poly(lactic-co-glycolic acid) microparticles that contain magnesium powder (Mg@PLGA MPs). Mg@PLGA MPs that are intra-muscularly injected close to the OA knee in a mouse model can act as an insitu depot that can evolve gaseous H-2 continuously, mediated by the cycle of passivation/activation of Mg in body fluids, at a concentration that exceeds its therapeutic threshold. The analytical data that are obtained in the biochemical and histological studies indicate that the proposed Mg@PLGA MPs can effectively mitigate tissue inflammation and prevent cartilage from destruction, arresting the progression of OA changes.

引用

页码：9875 / 9879

页数：5

共 23 条

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