Primary central nervous system lymphoma: essential points in diagnosis and management

被引：20

作者：

Paydas, Semra ^{[1
]}

机构：

[1] Cukurova Univ, Fac Med, Dept Med Oncol, Adana, Turkey

来源：

MEDICAL ONCOLOGY | 2017年 / 34卷 / 04期

关键词：

Primary central nervous system lymphoma; Pathogenesis; Prognosis; Management; Chemotherapy; Radiotherapy; PRIMARY CNS LYMPHOMA; HIGH-DOSE METHOTREXATE; STEM-CELL TRANSPLANTATION; PRIMARY VITREORETINAL LYMPHOMA; WHOLE-BRAIN RADIOTHERAPY; INTERNATIONAL EXTRANODAL LYMPHOMA; PRIMARY INTRAOCULAR LYMPHOMA; RECURRENT PRIMARY CNS; NON-HODGKINS-LYMPHOMA; MULTICENTER PHASE-II;

D O I：

10.1007/s12032-017-0920-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Primary central nervous system lymphoma (PCNSL) is an extra-nodal non-Hodgkin lymphoma. PCNSL is defined as lymphoma involving the brain, leptomeninges, eyes, or spinal cord without evidence of lymphoma outside the CNS. Treatment includes induction with chemotherapy and consolidation with whole-brain radiotherapy or high-dose chemotherapy supported by autologous stem cell transplantation. High-dose methotrexate is the most important drug in cases with PCNSL, and this drug will be used in combination with small molecules, BTK inhibitors, new monoclonal antibodies, and checkpoint blockers.

引用

页数：21

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