TAM receptors and their ligand-mediated activation: Role in atherosclerosis

被引：8
作者：
Cai, Bishuang [1 ]
Kasikara, Canan [2 ]
机构：
[1] Icahn Sch Med Mt Sinai, Dept Med, Div Liver Dis, New York, NY 10029 USA
[2] Columbia Univ, Dept Pathol & Cell Biol, New York, NY USA
来源：
TAM RECEPTORS IN HEALTH AND DISEASE | 2020年 / 357卷
关键词：
TO-RETENTION HYPOTHESIS; APOPTOTIC CELLS; LIPID MEDIATORS; MERTK RECEPTOR; SOLUBLE AXL; INFLAMMATION; RESOLUTION; EFFEROCYTOSIS; MACROPHAGES; CORONARY;
D O I：
10.1016/bs.ircmb.2020.09.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
TAM family tyrosine kinase receptors including Tyro3, Axl, and MerTK are the key efferocytosis receptors presenting on antigen-presenting cell that mediate the clearance of apoptotic cells. They are thought to regulate inflammatory diseases by modulating inflammatory response and efferocytosis. Recent studies have revealed novel roles of TAM receptors in the biosynthesis of specialized pro-resolving mediators (SPMs) and inflammation resolution. In this chapter, we discuss the central roles of TAM signaling in atherosclerosis focusing on their regulation in efferocytosis and inflammation resolution and highlight the unique therapeutic potential of SPMs in blocking the progression of atherosclerosis.
引用
收藏
页码：21 / 33
页数：13
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