Selection of mutant cell lines resistant to infection by Chlamydia trachomatis and Chlamydia pneumoniae

被引：26
作者：
Fudyk, T
Olinger, L
Stephens, RS
机构：
[1] Univ Calif Berkeley, Div Infect Dis, Sch Publ Hlth, Berkeley, CA 94720 USA
[2] Univ Calif San Francisco, Francis I Proctor Fdn, San Francisco, CA 94143 USA
来源：
INFECTION AND IMMUNITY | 2002年 / 70卷 / 11期
关键词：
D O I：
10.1128/IAI.70.11.6444-6447.2002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The lytic outcome of natural infection by Chlamydia trachomatis was exploited to select CHO (Chinese hamster ovary) cells, following chemical mutagenesis, that were deficient in their ability to sustain productive chlamydial infection. Four distinct mutant cell phenotypes with defects in either attachment or postattachment mechanisms that are required for infection by C. trachomatis and Chlamydia pneumoniae were characterized.
引用
收藏
页码：6444 / 6447
页数：4
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