Natural killer cell receptors and MHC class I interactions

被引：66
作者：
Lanier, LL
机构：
[1] DNAX Res. Inst. Molec. Cell. Biol., Dept. Hum. Immunol., 901 C., Palo Alto
来源：
CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 01期
关键词：
D O I：
10.1016/S0952-7915(97)80169-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Natural killer cells express two distinct families of genes encoding receptors for polymorphic MHC class I molecules. Recent advances indicate that immunoreceptor tyrosine-based inhibitory motifs in the cytoplasmic domains of the killer cell inhibitory receptors and Ly-49 receptors recruit the SH2-containing protein tyrosine phosphatase, SHP-1 and SHP-2, resulting in inhibition of natural-killer and T-cell-mediated cytotoxicity and cytokine secretion.
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收藏
页码：126 / 131
页数：6
相关论文
共 63 条
[1]  
ARAMBURU J, 1990, J IMMUNOL, V144, P3238
[2]  
Baker E, 1995, CHROMOSOME RES, V3, P511
[3]   The human leukocyte antigen (HLA)-C-specific ''activatory'' or ''inhibitory'' natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions [J].
Biassoni, R ;
Cantoni, C ;
Falco, M ;
Verdiani, S ;
Bottino, C ;
Vitale, M ;
Conte, R ;
Poggi, A ;
Moretta, A ;
Moretta, L .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (02) :645-650
[4]   AMINO-ACID SUBSTITUTIONS CAN INFLUENCE THE NATURAL-KILLER (NK)-MEDIATED RECOGNITION OF HLA-C MOLECULES - POLE OF SERINE-77 AND LYSINE-80 IN THE TARGET-CELL PROTECTION FROM LYSIS MEDIATED BY GROUP-2 OR GROUP-1 NK CLONES [J].
BIASSONI, R ;
FALCO, M ;
CAMBIAGGI, A ;
COSTA, P ;
VERDIANI, S ;
PENDE, D ;
CONTE, R ;
DIDONATO, C ;
PARHAM, P ;
MORETTA, L .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (02) :605-609
[5]   A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation [J].
Bottino, C ;
Sivori, S ;
Vitale, M ;
Cantoni, C ;
Falco, R ;
Pende, D ;
Morelli, L ;
Augugliaro, R ;
Semenzato, G ;
Biassoni, R ;
Moretta, L ;
Moretta, A .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (08) :1816-1824
[6]   Recognition of class I major histocompatibility complex molecules by Ly-49: Specificities and domain interactions [J].
Brennan, J ;
Mahon, G ;
Mager, DL ;
Jefferies, WA ;
Takei, F .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (04) :1553-1559
[7]   EXPRESSION OF DIFFERENT MEMBERS OF THE LY-49 GENE FAMILY DEFINES DISTINCT NATURAL-KILLER-CELL SUBSETS AND CELL-ADHESION PROPERTIES [J].
BRENNAN, J ;
MAGER, D ;
JEFFERIES, W ;
TAKEI, F .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (06) :2287-2295
[8]   CARBOHYDRATE-RECOGNITION BY A NATURAL-KILLER-CELL RECEPTOR, LY-49C [J].
BRENNAN, J ;
TAKEI, F ;
WONG, S ;
MAGER, DL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (17) :9691-9694
[9]   Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor [J].
Burshtyn, DN ;
Scharenberg, AM ;
Wagtmann, N ;
Rajagopalan, S ;
Berrada, K ;
Yi, TL ;
Kinet, JP ;
Long, EO .
IMMUNITY, 1996, 4 (01) :77-85
[10]   Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C [J].
Campbell, KS ;
Dessing, M ;
LopezBotet, M ;
Cella, M ;
Colonna, M .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (01) :93-100
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