Luminescent nanocarriers for simultaneous drug or gene delivery and imaging tracking

被引：12
作者：
Bai, Xilin [1 ]
Wang, Shiguo [1 ]
Xu, Suying [1 ]
Wang, Leyu [1 ]
机构：
[1] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing Key Lab Environm Harmful Chem Anal, Beijing 100029, Peoples R China
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2015年 / 73卷
基金：
中国国家自然科学基金;
关键词：
Bioavailability; Drug delivery; Gene delivery; Imaging; Luminescence; Luminescent nanocarrier; Nanostructure; Therapeutic agent; Toxicity; Tracking; UP-CONVERSION NANOPARTICLES; SILICON QUANTUM DOTS; FLUORESCENT METAL NANOCLUSTERS; MULTIDRUG-RESISTANCE; SIRNA DELIVERY; IN-VITRO; NANOCOMPOSITES; PH; RELEASE; NANOMATERIALS;
D O I：
10.1016/j.trac.2015.04.027
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Drug or gene delivery based on nanostructure is promising for treatments of cancers to solve a variety of issues associated with traditional therapeutic agents from poor bioavailability to systemic toxicity. For real-time monitoring of the delivery process, imaging-guided therapy has attracted growing interest in biomedical applications. Luminescent nanostructures serve as an essential tool for illuminating the pathway of drug or gene delivery in biomedical systems. Considering their crucial role in medical applications, we summarize recent progress of luminescent nanostructures as drug- or gene-delivery nanocarriers with simultaneous imaging tracking. We also discuss the design principles and the critical issues faced by multifunctional nanostructure engineering, which might provide guidance for further development in this field. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：54 / 63
页数：10
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