Survival following radiotherapy in young women with localized early-stage breast cancer according to molecular subtypes

被引:9
作者
Liu, Qi-Qi [1 ,2 ]
Sun, He-Fen [1 ,2 ]
Yang, Xue-Li [1 ,2 ]
Chen, Meng-Ting [1 ,2 ]
Liu, Yang [1 ,2 ]
Zhao, Yang [1 ,2 ]
Zhao, Yuan-Yuan [1 ,2 ]
Jin, Wei [1 ,2 ]
机构
[1] Fudan Univ, Shanghai Canc Ctr, Key Lab Breast Canc Shanghai, Dept Breast Surg, Shanghai 200030, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China
来源
CANCER MEDICINE | 2019年 / 8卷 / 06期
基金
中国国家自然科学基金;
关键词
breast cancer; radiation therapy; molecular subtype; survival; RECURRENCE; PORTRAITS; PATTERNS; THERAPY; RISK; AGE;
D O I
10.1002/cam4.2186
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background To evaluate the significance and benefit of radiotherapy (RT) in young early-stage breast cancer patients according to different molecular subtypes. Methods We conducted a retrospective cohort study utilizing the Surveillance, Epidemiology, and End Results database with known hormone receptor (HoR) and human epidermal growth factor receptor 2 (HER2) status. Female patients aged 18-45, received RT treatment, and diagnosed with stage T1-3, N0-3, M0 primary breast cancer between 2010 and 2013 were identified. Results Of all the 23 148 included patients, 14 708 (63.54%), 3385 (14.62%), 1225 (5.29%), and 3830 (16.55%) were diagnosed with luminal-A (HoR + HER2-), luminal-B (HoR + HER2+), HER2-enriched (HoR-HER2+), and triple-negative (HoR-HER2-) breast cancer, respectively. RT was significantly correlated with improved overall survival (OS, HR: 0.295; 95% CI:0.138-0.63, P = 0.002) and breast cancer-specific survival (BCSS, HR: 0.328; 95% CI: 0.153-0.702, P = 0.004) in HER2-enriched patients. In addition, a significantly prolonged OS was also observed when RT was given to luminal-A (HR: 0.696; 95% CI: 0.538-0.902, P = 0.006) and luminal-B (HR: 0.385; 95% CI:0.199-0.744, P = 0.005) breast cancer patients compared to those without RT. Multivariable-adjusted analyses showed that HER2 was a significant favorable factor for RT benefit in breast cancer patients. Conclusions RT could offer significant survival benefit in luminal-A, luminal-B, and especially HER2-enriched young early-stage breast cancer female patients. The results enabled clinicians to predict the benefits of RT and improve evidence-based treatment for breast cancer patients.
引用
收藏
页码:2840 / 2857
页数:18
相关论文
共 50 条
[41]   Do prognosis and clinicopathological features differ in young early-stage breast cancer? [J].
Arikan, Akif Enes ;
Kara, Halil ;
Dulgeroglu, Onur ;
Erdogan, Esin Nur ;
Capkinoglu, Emir ;
Uras, Cihan .
FRONTIERS IN SURGERY, 2022, 9
[42]   A Prospective Study of Weight Gain in Women Diagnosed with Early-Stage Invasive Breast Cancer, Ductal Carcinoma In Situ, and Women Without Breast Cancer [J].
Ekenga, Christine C. ;
Wang, Xiaoyan ;
Perez, Maria ;
Schootman, Mario ;
Jeffe, Donna B. .
JOURNAL OF WOMENS HEALTH, 2020, 29 (04) :524-533
[43]   Update on intraoperative radiotherapy for early-stage breast cancer [J].
Feng, Kexin ;
Meng, Xiangzhi ;
Liu, Jiaqi ;
Xing, Zeyu ;
Zhang, Menglu ;
Wang, Xin ;
Feng, Qinfu ;
Wang, Xiang .
AMERICAN JOURNAL OF CANCER RESEARCH, 2020, 10 (07) :2032-2042
[44]   Comparative cost-effectiveness of radiotherapy among older women with hormone receptor positive early-stage breast cancer [J].
Ali, Askal Ayalew ;
Tawk, Rima ;
Xiao, Hong ;
Semykina, Anastasia ;
Montero, Alberto J. ;
Moussa, Richard K. ;
Popoola, Olayiwola ;
Diaby, Vakaramoko .
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH, 2022, 22 (05) :735-741
[45]   The Management of Early-Stage and Metastatic Triple-Negative Breast Cancer: A Review [J].
Anders, Carey K. ;
Zagar, Timothy M. ;
Carey, Lisa A. .
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2013, 27 (04) :737-+
[46]   Dietary Intake, Supplement Use, and Survival Among Women Diagnosed With Early-Stage Breast Cancer [J].
Saquib, Juliann ;
Rock, Cheryl L. ;
Natarajan, Loki ;
Saquib, Nazmus ;
Newman, Vicky A. ;
Patterson, Ruth E. ;
Thomson, Cynthia A. ;
Al-Delaimy, Wael K. ;
Pierce, John P. .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2011, 63 (03) :327-333
[47]   Young Women with Early-Stage Breast Cancer Treated with Upfront Surgery: Overview of Oncological Outcomes [J].
Scardina, Lorenzo ;
Carnassale, Beatrice ;
Di Leone, Alba ;
Sanchez, Alejandro Martin ;
Biondi, Ersilia ;
Moschella, Francesca ;
D'Archi, Sabatino ;
Franco, Antonio ;
De Lauretis, Flavia ;
Di Guglielmo, Enrico ;
Petrazzuolo, Eleonora ;
Magno, Stefano ;
Masetti, Riccardo ;
Franceschini, Gianluca .
JOURNAL OF CLINICAL MEDICINE, 2024, 13 (13)
[48]   INTRAOPERATIVE RADIOTHERAPY IN EARLY-STAGE BREAST CANCER: RESULTS OF THE MONTPELLIER PHASE II TRIAL [J].
Lemanski, Claire ;
Azria, David ;
Gourgon-Bourgade, Sophie ;
Gutowski, Marian ;
Rouanet, Phillippe ;
Saint-Aubert, Bernard ;
Ailleres, Norbert ;
Fenoglietto, Pascal ;
Dubois, Jean-Bernard .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2010, 76 (03) :698-703
[49]   The Prognostic Impact of Molecular Subtypes and Very Young Age on Breast Conserving Surgery in Early Stage Breast Cancer [J].
Ordu, Cetin ;
McGuire, Kandace ;
Alco, Gul ;
Pilanci, Kezban Nur ;
Koksal, Ulkuhan I. ;
Elbuken, Filiz ;
Erdogan, Zeynep ;
Agacayak, Filiz ;
Ilgun, Serkan ;
Sarsenov, Dauren ;
Ozturk, Alper ;
Igdem, Sefik ;
Okkan, Sait ;
Eralp, Yesim ;
Dincer, Maktav ;
Ozmen, Vahit .
CUREUS, 2016, 8 (06)
[50]   Metabolic syndrome and outcomes following early-stage breast cancer [J].
Calip, Gregory S. ;
Malone, Kathleen E. ;
Gralow, Julie R. ;
Stergachis, Andy ;
Hubbard, Rebecca A. ;
Boudreau, Denise M. .
BREAST CANCER RESEARCH AND TREATMENT, 2014, 148 (02) :363-377