Survival following radiotherapy in young women with localized early-stage breast cancer according to molecular subtypes

被引:9
作者
Liu, Qi-Qi [1 ,2 ]
Sun, He-Fen [1 ,2 ]
Yang, Xue-Li [1 ,2 ]
Chen, Meng-Ting [1 ,2 ]
Liu, Yang [1 ,2 ]
Zhao, Yang [1 ,2 ]
Zhao, Yuan-Yuan [1 ,2 ]
Jin, Wei [1 ,2 ]
机构
[1] Fudan Univ, Shanghai Canc Ctr, Key Lab Breast Canc Shanghai, Dept Breast Surg, Shanghai 200030, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China
来源
CANCER MEDICINE | 2019年 / 8卷 / 06期
基金
中国国家自然科学基金;
关键词
breast cancer; radiation therapy; molecular subtype; survival; RECURRENCE; PORTRAITS; PATTERNS; THERAPY; RISK; AGE;
D O I
10.1002/cam4.2186
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background To evaluate the significance and benefit of radiotherapy (RT) in young early-stage breast cancer patients according to different molecular subtypes. Methods We conducted a retrospective cohort study utilizing the Surveillance, Epidemiology, and End Results database with known hormone receptor (HoR) and human epidermal growth factor receptor 2 (HER2) status. Female patients aged 18-45, received RT treatment, and diagnosed with stage T1-3, N0-3, M0 primary breast cancer between 2010 and 2013 were identified. Results Of all the 23 148 included patients, 14 708 (63.54%), 3385 (14.62%), 1225 (5.29%), and 3830 (16.55%) were diagnosed with luminal-A (HoR + HER2-), luminal-B (HoR + HER2+), HER2-enriched (HoR-HER2+), and triple-negative (HoR-HER2-) breast cancer, respectively. RT was significantly correlated with improved overall survival (OS, HR: 0.295; 95% CI:0.138-0.63, P = 0.002) and breast cancer-specific survival (BCSS, HR: 0.328; 95% CI: 0.153-0.702, P = 0.004) in HER2-enriched patients. In addition, a significantly prolonged OS was also observed when RT was given to luminal-A (HR: 0.696; 95% CI: 0.538-0.902, P = 0.006) and luminal-B (HR: 0.385; 95% CI:0.199-0.744, P = 0.005) breast cancer patients compared to those without RT. Multivariable-adjusted analyses showed that HER2 was a significant favorable factor for RT benefit in breast cancer patients. Conclusions RT could offer significant survival benefit in luminal-A, luminal-B, and especially HER2-enriched young early-stage breast cancer female patients. The results enabled clinicians to predict the benefits of RT and improve evidence-based treatment for breast cancer patients.
引用
收藏
页码:2840 / 2857
页数:18
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