Triple Artemisinin-Based Combination Therapies for Malaria - A New Paradigm?

被引：83
|
作者：
van der Pluijm, Rob W. [1 ,2 ]
Amaratunga, Chanaki [1 ,2 ]
Dhorda, Mehul [1 ,2 ,3 ]
Dondorp, Arjen M. [1 ,2 ]
机构：
[1] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand
[2] Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England
[3] WorldWide Antimalarial Resistance Network Asia Pa, Bangkok, Thailand
来源：
TRENDS IN PARASITOLOGY | 2021年 / 37卷 / 01期
关键词：
PLASMODIUM-FALCIPARUM MALARIA; ARTEMETHER-LUMEFANTRINE; IN-VITRO; CHLOROQUINE RESISTANCE; DRUG-RESISTANCE; ARTESUNATE; MEFLOQUINE; EFFICACY; CAMBODIA; PHARMACOKINETICS;
D O I：
10.1016/j.pt.2020.09.011
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Recent gains in the fight against malaria are threatened by the emergence and spread of artemisinin and partner drug resistance in Plasmodium falciparum in the Greater Mekong Subregion (GMS). When artemisinins are combined with a single partner drug, all recommended artemisinin-based combination therapies have shown reduced efficacy in some countries in the GMS at some point. Novel drugs are not available for the near future. Triple artemisinin-based combination therapies, combining artemisinins with two currently available partner drugs, will provide one of the last remaining safe and effective treatments for falciparum malaria that can be deployed rapidly in the GMS, whereas their deployment beyond the GMS could delay or prevent the global emergence and spread of resistance to currently available drugs.
引用
收藏
页码：15 / 24
页数：10
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