From stem cells to lymphocytes: Biology and transplantation

被引：57

作者：

Aguila, HL

Akashi, K

Domen, J

Gandy, KL

Lagasse, E

Mebius, RE

Morrison, SJ

Shizuru, J

Strober, S

Uchida, N

Wright, DE

Weissman, IL

机构：

[1] STANFORD UNIV, SCH MED, DEPT PATHOL, STANFORD, CA 94305 USA

[2] STANFORD UNIV, SCH MED, DEPT DEV BIOL, STANFORD, CA 94305 USA

[3] CALTECH, DIV BIOL 216 76, PASADENA, CA 91125 USA

[4] VRIJE UNIV AMSTERDAM, FAC MED, DEPT CELL BIOL & IMMUNOL, AMSTERDAM, NETHERLANDS

[5] STANFORD UNIV, SCH MED, DEPT MED, DIV BONE MARROW TRANSPLANTAT, STANFORD, CA 94305 USA

[6] STANFORD UNIV, SCH MED, DEPT MED, DIV RHEUMATOL & IMMUNOL, STANFORD, CA 94305 USA

[7] SYST INC, PALO ALTO, CA USA

来源：

IMMUNOLOGICAL REVIEWS | 1997年 / 157卷

关键词：

D O I：

10.1111/j.1600-065X.1997.tb00971.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We review the development of the hematopoietic system, focusing on the transition from hematopoietic stem cells (HSCs) to T cells. This includes the isolation of HSCs, and recent progress in understanding their ontogeny, homing properties, and differentiation. HSC transplanta tion is reviewed, including the kinetics of reconstitution, engraftment across histocompatibility barriers, the facilitation of allogeneic engraft ment, and the mechanisms of graft rejection. We describe progress in understanding T-cell development in the bone marrow and thymus as well as the establishment of lymph nodes. Finally, the role of bcl-2 in regulating homeostasis in the hematopoietic system is discussed.

引用

页码：13 / 40

页数：28

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